| Tag | Content |
|---|---|
| UniProt Accession | CDN1A_MOUSE; P39689; |
| Entrez ID | 12575 |
| GenBank Protein ID | NM_001111099.2; NM_007669.5; |
| GenBank Nucleotide ID | NP_001104569.1; NP_031695.1; |
| Protein Name | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein) (p21) |
| Gene Name | Cdkn1a; Cip1; Waf1 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316). Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity). |
| Sequence (Fasta) | MSNPGDVRPV PHRSKVCRCL FGPVDSEQLR RDCDALMAGC LQEARERWNF DFVTETPLEG 60 NFVWERVRSL GLPKVYLSPG SRSRDDLGGD KRPSTSSALL QGPAPEDHVA LSLSCTLVSE 120 RPEDSPGGPG TSQGRKRRQT SLTDFYHSKR RLVFCKRKP |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 15) (view all) | MESH:D002295
; Carcinoma, Transitional Cell MESH:D003110 ; Colonic Neoplasms MESH:C562729 ; Esophageal Squamous Cell Carcinoma MESH:D015658 ; HIV Infections MESH:D007414 ; Intestinal Neoplasms MESH:D007674 ; Kidney Diseases |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 5) | 140 QGRKRRQTSLTDFYH dbPAF
141 GRKRRQTSLTDFYHS dbPAF 2 ******MSNPGDVRP dbPAF 76 SLGLPKVYLSPGSRS dbPAF 78 GLPKVYLSPGSRSRD dbPAF |