P39687

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession AN32A_HUMAN; P39687;
Entrez ID 8125
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated pr
Gene Name ANP32A; C15orf1; LANP; MAPM; PHAP1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionImplicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.
Sequence
(Fasta)		MEMGRRIHLE LRNRTPSDVK ELVLDNSRSN EGKLEGLTDE FEELEFLSTI NVGLTSIANL 60
PKLNKLKKLE LSDNRVSGGL EVLAEKCPNL THLNLSGNKI KDLSTIEPLK KLENLKSLDL 120
FNCEVTNLND YRENVFKLLP QLTYLDGYDR DDKEAPDSDA EGYVEGLDDE EEDEDEEEYD 180
EDAQVVEDEE DEDEEEEGEE EDVSGEEEED EEGYNDGEVD DEEDEEELGE EERGQKRKRE 240
PEDEGEDDD

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationColon cancer/carcinomaP15247276
[Reference]: While investigating the reversible antiproliferative effect of the dietary lectin, jacalin, which binds the Thomsen-Friedenreich antigen (galactose beta1-3 N-acetylgalactosamine alpha-), we have found that this lectin (30 microg/ml) induces rapid, transient, tyrosine phosphorylation of putative human HLA-DR-associated protein I (PHAPI, also known as the tumor suppressor pp32) in HT29 human colon cancer cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D015179 ; Colorectal Neoplasms
GWASdb
(count: 4)		rs2290428; Alzheimer's disease; Alzheimer's disease
rs7162391; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease
rs7164503; Alzheimer's disease; Alzheimer's disease
rs6494774; Smoking initiation; nicotine dependence

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)		 104       GNKIKDLSTIEPLKK     dbPAF
117       KKLENLKSLDLFNCE     dbPAF
126       DLFNCEVTNLNDYRE     dbPAF
148       QLTYLDGYDRDDKEA     dbPAF
15        HLELRNRTPSDVKEL     dbPAF
158       DDKEAPDSDAEGYVE     dbPAF
Acetylation
(count: 5)		 110       LSTIEPLKKLENLKS     PLMD
20        NRTPSDVKELVLDNS     PLMD
238       EERGQKRKREPEDEG     PLMD
86        GLEVLAEKCPNLTHL     PLMD
99        HLNLSGNKIKDLSTI     PLMD
Ubiquitination
(count: 5)		 110       LSTIEPLKKLENLKS     PLMD
116       LKKLENLKSLDLFNC     PLMD
137       DYRENVFKLLPQLTY     PLMD
20        NRTPSDVKELVLDNS     PLMD
68        PKLNKLKKLELSDNR     PLMD
Sumoylation
(count: 1)		 65        ANLPKLNKLKKLELS     PLMD
Succinylation
(count: 1)		 110       LSTIEPLKKLENLKS     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource