| Tag | Content |
|---|---|
| UniProt Accession | CDN1A_HUMAN; P38936; |
| Entrez ID | 1026 |
| GenBank Protein ID | NM_000389.4; NM_001220777.1; NM_001220778.1; NM_001291549.1; NM_078467.2; |
| GenBank Nucleotide ID | NP_000380.1; NP_001207706.1; NP_001207707.1; NP_001278478.1; NP_510867.1; |
| Protein Name | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) |
| Gene Name | CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). |
| Sequence (Fasta) | MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE 60 GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV 120 PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP 165 |
|
|||||||||||||||||||||||||||||||||
| Database | Annotation |
|---|---|
| Cancer Gene Census | bladder cancer |
| CTD (Curated) (count: 15) (view all) | MESH:D002295
; Carcinoma, Transitional Cell MESH:D003110 ; Colonic Neoplasms MESH:C562729 ; Esophageal Squamous Cell Carcinoma MESH:D015658 ; HIV Infections MESH:D007414 ; Intestinal Neoplasms MESH:D007674 ; Kidney Diseases |
| DisGeNet (Curated) (count: 39) (view all) | C0001206; Acromegaly
C0005695; Bladder Neoplasm C0007138; Carcinoma, Transitional Cell C0009375; Colonic Neoplasms C0011991; Diarrhea C0014868; Esophagitis |
| HGMD (count: 5) | CM940226; Cancer, association with; Missense/nonsense
CM092604; Multiple endocrine neoplasia 1; Missense/nonsense CM065058; Breast cancer, association with; Missense/nonsense CM024565; Altered activity, association with; Missense/nonsense CR952240; Cancer, association with; Regulatory |
| GWASdb (count: 6) | rs3829963; Basophils; hematopoietic system disease|heart disease
rs2395655; Response to lithium treatment in bipolar disorder; bipolar disorder rs3176326; Atrial fibrillation; familial atrial fibrillation rs3176353; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs3176353; Cholesterol, total; coronary artery disease|lipid metabolism disorder|arteriosclerosis rs876581; Sudden cardiac arrest; coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 11) (view all) | 114 EEDHVDLSLSCTLVP dbPAF
123 SCTLVPRSGEQAEGS dbPAF 130 SGEQAEGSPGGPGDS dbPAF 145 QGRKRRQTSMTDFYH dbPAF 146 GRKRRQTSMTDFYHS dbPAF 153 SMTDFYHSKRRLIFS dbPAF |
| Ubiquitination (count: 3) | 154 MTDFYHSKRRLIFSK PLMD
161 KRRLIFSKRKP**** PLMD 75 VRGLGLPKLYLPTGP PLMD |