P38659

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PDIA4_RAT; P38659;
Entrez ID 116598
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Protein disulfide-isomerase A4 (EC 5.3.4.1) (Calcium-binding protein 2) (CaBP2) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene Name Pdia4; Cabp2; Erp70
Organism Rattus norvegicus
NCBI Taxa ID 10116
Sequence
(Fasta)		MKLRKAWLLV LLLALTQLLA AASAEDAHED ASDSENPIED DDDEEEDEED EDDLEVKEEN 60
GVWVLNDENF DNFVADKDTV LLEFYAPWCG HCKQFAPEYE KIASTLKDND PPIAVAKIDA 120
TSASMLASKF DVSGYPTIKI LKKGQAVDYD GSRTQEEIVA KVREVSQPDW TPPPEVTLTL 180
TKENFDDVVN NADIILVEFY APWCGHCKKL APEYEKAAKE LSKRSPPIPL AKVDATEQTD 240
LAKRFDVSGY PTLKIFRKGR PFDYNGPREK YGIVDYMVEQ SGPPSKEILT LKQVQEFLKD 300
GDDVVILGVF QGVGDPGYLQ YQDAANTLRE DYKFHHTFST EIAKFLKVSL GKLVLMQPEK 360
FQSKYEPRMH VMDVQGSTEA SAIKDYVVKH ALPLVGHRKT SNDAKRYSKR PLVVVYYSVD 420
FSFDYRTATQ FWRNKVLEVA KDFPEYTFAI ADEEDYATEV KDLGLSESGE DVNAAILDES 480
GKKFAMEPEE FDSDALQEFV MAFKKGKLKP VIKSQPVPKN NKGPVRVVVG KTFDAIVMDP 540
KKDVLIEFYA PWCGHCKQLE PVYTSLGKKY KGQKDLVIAK MDATANDITN DRYKVEGFPT 600
IYFAPSGDKK NPIKFEGGNR DLEHLSKFID EHATKRSRTK EEL 644

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1N-linked glycosylationHepatocellular carcinoma/Hepatocarcinoma/HepatomaP8477750
[Reference]: The amount of CaBP2 in H-35 Reuber hepatoma cells increases in parallel with that of immunoglobin heavy-chain-binding protein under conditions which lead to impaired glycosylation, while the amount of calreticulin, another KDEL-containing glycoprotein, remains almost unchanged.


※ PTM Sites

PTM Modification Sites
Acetylation
(count: 4)		 254       VSGYPTLKIFRKGRP     PLMD
270       DYNGPREKYGIVDYM     PLMD
389       AIKDYVVKHALPLVG     PLMD
627       RDLEHLSKFIDEHAT     PLMD
Succinylation
(count: 2)		 143       PTIKILKKGQAVDYD     PLMD
482       AILDESGKKFAMEPE     PLMD