P37840

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SYUA_HUMAN; P37840;
Entrez ID 6622
GenBank Protein ID NM_000345.3; NM_001146054.1; NM_001146055.1; NM_007308.2; XM_011532208.2; XM_017008562.1; XM_017008563.1;
GenBank Nucleotide ID NP_000336.1; NP_001139526.1; NP_001139527.1; NP_009292.1; XP_011530510.1; XP_016864051.1; XP_016864052.1;
Protein Name Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene Name SNCA; NACP; PARK1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMay be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Sequence
(Fasta)		MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK 60
EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP 120
DNEAYEMPSE EGYQDYEPEA 141

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1UbiquitinationPheochromocytomaPC12 cell lineP18065497
[Reference]: Siah-1-mediated -synuclein ubiquitination enhances apoptotic cell death
2Tyrosine PhosphorylationParkinson's diseaseUY3928636593; 27348587
[Reference]: Moreover, c-Abl activation led to an age-dependent increase in phosphotyrosine 39 ?-synucleinThis study further indicates that phosphotyrosine 39 ?-synuclein is a potential disease indicator for PD and related ?-synucleinopathies.
3Serine PhosphorylationAlzheimer's diseaseUS12919889641
[Reference]: PLKs specifically co-localized with phosphorylated Ser-129 (Ser(P)-129) alpha-syn in various subcellular compartments.Furthermore, we report that the levels of PLK2 are significantly increased in brains of Alzheimer disease and Lewy body disease patients.
4Serine PhosphorylationParkinson's diseaseUS12924204929; 11813001; 28636593; 14579119; 12505616; 22344688; 21562258; 25637461; 21865317; 21849493
[Reference]: The -synuclein (SNCA) protein is intricately involved in the pathogenesis of Parkinson?? disease and other synucleinopathies, including dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Each disorder is characterized by protein aggregates containing -synuclein protein that has been hyperphosphorylated on serine 129 (p-Syn);;;;PD patients had higher S129 phosphorylation levels compared to healthy controls. Patients with multiple system atrophy (MSA) or progressive supranuclear palsy (PSP) patient, had lower S129 phosphorylation than PD patients or healthy controls. There was a weak correlation with P-S129 levels and severity of the PD.;;;;Lower pS129 levels correlated with worse clinical condition at early stages, but better condition at later stages.;

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 16)
(view all)		MESH:D000437 ; Alcoholism
MESH:D019969 ; Amphetamine-Related Disorders
MESH:D019970 ; Cocaine-Related Disorders
MESH:D004195 ; Disease Models, Animal
MESH:D005776 ; Gaucher Disease
MESH:D006527 ; Hepatolenticular Degeneration
HGMD
(count: 13)
(view all)		CE005493; Parkinson disease, association with; Repeat variations
CN035409; Parkinson disease; Gross insertions
CN045362; Parkinson disease; Gross insertions
CN082440; Parkinson disease & dementia; Gross insertions
CN084733; Parkinson disease & dementia; Gross insertions
CN090347; Parkinson disease; Gross insertions
GWASdb
(count: 52)
(view all)		rs3857053; Parkinson's disease; Parkinson's disease
rs356165; Parkinson's disease; Parkinson's disease
rs7684318; Parkinson's disease; Parkinson's disease
rs3775423; Parkinson's disease; Parkinson's disease
rs356204; Parkinson's disease; Parkinson's disease
rs3822086; Parkinson's disease; Parkinson's disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 8)
(view all)		 125       VDPDNEAYEMPSEEG     dbPAF
129       NEAYEMPSEEGYQDY     dbPAF
133       EMPSEEGYQDYEPEA     dbPAF
136       SEEGYQDYEPEA***     dbPAF
39        KTKEGVLYVGSKTKE     dbPAF
42        EGVLYVGSKTKEGVV     dbPAF
Acetylation
(count: 2)		 21        GVVAAAEKTKQGVAE     PLMD
58        GVATVAEKTKEQVTN     PLMD
Sumoylation
(count: 11)
(view all)		 10        VFMKGLSKAKEGVVA     PLMD
102       VKKDQLGKNEEGAPQ     PLMD
12        MKGLSKAKEGVVAAA     PLMD
21        GVVAAAEKTKQGVAE     PLMD
23        VAAAEKTKQGVAEAA     PLMD
34        AEAAGKTKEGVLYVG     PLMD
Glycation
(count: 1)		 45        LYVGSKTKEGVVHGV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
E9PG40P37840HPRD
H0YG33P37840MINT
O14656P37840HPRD
O60260P37840HPRD
O75821P37840MINT
P00414P37840HPRD
P02735P37840BioGRID
P04217P37840MINT
P04406P37840MINT
P06241P37840HPRD
P07101P37840HPRD
P07948P37840HPRD
P09769P37840HPRD
P0CG47P37840HPRD
P10636P37840MINT;HPRD
P11802P37840MINT
P19419P37840HPRD
P19784P37840HPRD
P21796P37840IntAct
P25098P37840HPRD
P28482P37840HPRD
P31946P37840HPRD
P34947P37840HPRD
P37840P37840DIP; IntAct
P37840P43250HPRD
P37840P43405HPRD
P37840P45880IntAct
P37840P46821HPRD
P37840P48730HPRD
P37840P49841MINT
P37840P51693MINT
P37840P62158HPRD
P37840P62258HPRD
P37840P68104MINT
P37840P68400HPRD
P37840P99999HPRD
P37840Q01082IntAct
P37840Q01959HPRD
P37840Q02156HPRD
P37840Q04917HPRD; MINT
P37840Q07817HPRD
P37840Q13393HPRD
P37840Q13501HPRD
P37840Q14289HPRD
P37840Q16143HPRD
P37840Q5VU43MINT
P37840Q71U36HPRD
P37840Q8IZQ1IntAct
P37840Q92876HPRD
P37840Q92934HPRD
P37840Q96N67MINT
P37840Q99497DIP
P37840Q9BRK5MINT
P37840Q9BXS0HPRD
P37840Q9GZQ8IntAct
P37840Q9H1Y0IntAct
P37840Q9UQF2HPRD
P37840Q9Y6H5HPRD