Tag | Content |
---|---|
UniProt Accession | PPARG_MOUSE; P37238; |
Entrez ID | 19016 |
GenBank Protein ID | NM_001127330.2; NM_001308352.1; NM_001308354.1; NM_011146.3; XM_006505743.3; XM_011241252.1; XM_017321455.1; |
GenBank Nucleotide ID | NP_001120802.1; NP_001295281.1; NP_001295283.1; NP_035276.2; XP_006505806.1; XP_011239554.1; XP_017176944.1; |
Protein Name | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) |
Gene Name | Pparg; Nr1c3 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (PubMed:19041764). |
Sequence (Fasta) | MGETLGDSPV DPEHGAFADA LPMSTSQEIT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF 60 DIKPFTTVDF SSISAPHYED IPFTRADPMV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT 120 QLYNRPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC 180 RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR 240 ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE 300 QSKEVAIRIF QGCQFRSVEA VQEITEYAKN IPGFINLDLN DQVTLLKYGV HEIIYTMLAS 360 LMNKDGVLIS EGQGFMTREF LKNLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII 420 LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKVLQKMTDL RQIVTEHVQL 480 LHVIKKTETD MSLHPLLQEI YKDLY 506 |
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Database | Annotation |
---|---|
CTD (Curated) (count: 43) (view all) | MESH:D058186
; Acute Kidney Injury MESH:D055371 ; Acute Lung Injury MESH:D000230 ; Adenocarcinoma MESH:D000544 ; Alzheimer Disease MESH:D016736 ; Antiphospholipid Syndrome MESH:D050197 ; Atherosclerosis |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 8) (view all) | 112 AIKVEPASPPYYSEK dbPAF
133 PHEEPSNSLMAIECR dbPAF 173 TIRLKLIYDRCDLNC dbPAF 273 TGKTTDKSPFVIYDM dbPAF 296 KIKFKHITPLQEQSK dbPAF 317 FQGCQFRSVEAVQEI dbPAF |
Sumoylation (count: 1) | 107 QEYQSAIKVEPASPP PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |