| Tag | Content |
|---|---|
| UniProt Accession | SRBP1_HUMAN; P36956; |
| Entrez ID | 6720 |
| GenBank Protein ID | NM_001005291.2; NM_004176.4; |
| GenBank Nucleotide ID | NP_001005291.1; NP_004167.3; |
| Protein Name | Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1] |
| Gene Name | SREBF1; BHLHD1; SREBP1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). |
| Sequence (Fasta) | MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP YAGSGAGGTD 60 PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP QPAPTPLKMY PSMPAFSPGP 120 GIKEESVPLS ILQTPTPQPL PGALLPQSFP APAPPQFSST PVLGYPSPPG GFSTGSPPGN 180 TQQPLPGLPL ASPPGVPPVS LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL 240 QPHFIKADSL LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA 300 EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV VGTEAKLNKS 360 AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL VSACGSGGNT DVLMEGVKTE 420 VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR 480 GMLDRSRLAL CTLVFLCLSC NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW 540 AQWLLPPVVW LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ 600 AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG GLQQDCALRV 660 DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL NLAECAGDAV SVATLAEIYV 720 AAALRVKTSL PRALHFLTRF FLSSARQACL AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL 780 STPWESLYSL AGNPVDPLAQ VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL 840 QLLNSCSDAA GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL 900 VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG YLQDSLATTP 960 ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT SSRPQASALE LRGFQRDLSS 1020 LRRLAQSFRP AMRRVFLHEA TARLMAGASP TRTHQLLDRS LRRRAGPGGK GGAVAELEPR 1080 PTRREHAEAL LLASCYLPPG FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG 1140 GTTVTSS 1148 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 8) (view all) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D003921 ; Diabetes Mellitus, Experimental MESH:D005234 ; Fatty Liver MESH:D007333 ; Insulin Resistance MESH:D007676 ; Kidney Failure, Chronic MESH:D008106 ; Liver Cirrhosis, Experimental |
| GWASdb (count: 3) | rs11868035; Parkinson's disease; Parkinson's disease
rs4925115; Type 2 diabetes; type 2 diabetes mellitus rs9902941; Parkinson's disease; Parkinson's disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 22) (view all) | 1019 RGFQRDLSSLRRLAQ dbPAF
1020 GFQRDLSSLRRLAQS dbPAF 1049 ARLMAGASPTRTHQL dbPAF 105 SPPQPAPTPLKMYPS dbPAF 1060 THQLLDRSLRRRAGP dbPAF 117 YPSMPAFSPGPGIKE dbPAF |
| Acetylation (count: 4) | 313 NRLAAGSKAPASAQS PLMD
324 SAQSRGEKRTAHNAI PLMD 333 TAHNAIEKRYRSSIN PLMD 365 NKSAVLRKAIDYIRF PLMD |
| Ubiquitination (count: 21) (view all) | 1070 RRAGPGGKGGAVAEL PLMD
1121 EAARTLEKLGDRRLL PLMD 256 SLLLTAMKTDGATVK PLMD 313 NRLAAGSKAPASAQS PLMD 342 YRSSINDKIIELKDL PLMD 347 NDKIIELKDLVVGTE PLMD |
| Sumoylation (count: 2) | 123 FSPGPGIKEESVPLS PLMD
418 DVLMEGVKTEVEDTL PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |