| Tag | Content |
|---|---|
| UniProt Accession | FLT3_HUMAN; P36888; |
| Entrez ID | 2322 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) |
| Gene Name | FLT3; CD135; FLK2; STK1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. |
| Sequence (Fasta) | MPALARDGGQ LPLLVVFSAM IFGTITNQDL PVIKCVLINH KNNDSSVGKS SSYPMVSESP 60 EDLGCALRPQ SSGTVYEAAA VEVDVSASIT LQVLVDAPGN ISCLWVFKHS SLNCQPHFDL 120 QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLYTLRR PYFRKMENQD 180 ALVCISESVP EPIVEWVLCD SQGESCKEES PAVVKKEEKV LHELFGTDIR CCARNELGRE 240 CTRLFTIDLN QTPQTTLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALEEGNYFEM 300 STYSTNRTMI RILFAFVSSV ARNDTGYYTC SSSKHPSQSA LVTIVEKGFI NATNSSEDYE 360 IDQYEEFCFS VRFKAYPQIR CTWTFSRKSF PCEQKGLDNG YSISKFCNHK HQPGEYIFHA 420 ENDDAQFTKM FTLNIRRKPQ VLAEASASQA SCFSDGYPLP SWTWKKCSDK SPNCTEEITE 480 GVWNRKANRK VFGQWVSSST LNMSEAIKGF LVKCCAYNSL GTSCETILLN SPGPFPFIQD 540 NISFYATIGV CLLFIVVLTL LICHKYKKQF RYESQLQMVQ VTGSSDNEYF YVDFREYEYD 600 LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA DSSEREALMS 660 ELKMMTQLGS HENIVNLLGA CTLSGPIYLI FEYCCYGDLL NYLRSKREKF HRTWTEIFKE 720 HNFSFYPTFQ SHPNSSMPGS REVQIHPDSD QISGLHGNSF HSEDEIEYEN QKRLEEEEDL 780 NVLTFEDLLC FAYQVAKGME FLEFKSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS 840 NYVVRGNARL PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK 900 LIQNGFKMDQ PFYATEEIYI IMQSCWAFDS RKRPSFPNLT SFLGCQLADA EEAMYQNVDG 960 RVSECPHTYQ NRRPFSREMD LGLLSPQAQV EDS 994 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | AML, ALL |
| CTD (Curated) (count: 6) | MESH:D015470
; Leukemia, Myeloid, Acute MESH:D007964 ; Leukocytosis MESH:D015473 ; Leukemia, Promyelocytic, Acute MESH:D054198 ; Precursor Cell Lymphoblastic Leukemia-Lymphoma MESH:D013163 ; Splenomegaly MESH:D013927 ; Thrombosis |
| DisGeNet (Curated) (count: 8) (view all) | C0023449; Acute lymphocytic leukemia
C0023464; Acute biphenotypic leukemia C0023467; Leukemia, Myelocytic, Acute C0023479; Acute myelomonocytic leukemia C0023487; Acute Promyelocytic Leukemia C0026998; Acute Myeloid Leukemia, M1 |
| HGMD (count: 1) | CM066823; Myeloid leukaemia, increased risk, association with; Missense/nonsense
|
| GWASdb (count: 8) (view all) | rs1999364; Multiple complex diseases; Null
rs3829382; Alzheimer's disease; Alzheimer's disease rs17086213; Alcohol dependence; alcohol dependence rs7317159; Alcohol dependence; alcohol dependence rs4771206; Multiple complex diseases; Null rs9513000; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 22) (view all) | 166 SIRNTLLYTLRRPYF dbPAF
343 PSQSALVTIVEKGFI dbPAF 401 QKGLDNGYSISKFCN dbPAF 416 HKHQPGEYIFHAEND dbPAF 572 KYKKQFRYESQLQMV dbPAF 574 KKQFRYESQLQMVQV dbPAF |
| Ubiquitination (count: 2) | 614 RENLEFGKVLGSGAF PLMD
623 LGSGAFGKVMNATAY PLMD |
| Glycation (count: 2) | 466 LPSWTWKKCSDKSPN PLMD
470 TWKKCSDKSPNCTEE PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |