P36507

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MP2K2_HUMAN; P36507;
Entrez ID 5605
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene Name MAP2K2; MEK2; MKK2; PRKMK2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCatalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
Sequence
(Fasta)		MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELELDEQQ KKRLEAFLTQ 60
KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ 120
VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG 180
LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMAPERLQ 240
GTHYSVQSDI WSMGLSLVEL AVGRYPIPPP DAKELEAIFG RPVVDGEEGE PHSISPRPRP 300
PGRPVSGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTP DFQEFVNKCL IKNPAERADL 360
KMLTNHTFIK RSEVEEVDFA GWLCKTLRLN QPGTPTRTAV 401

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationBreast cancer/tumor/carcinomaU15193230
[Reference]: The levels of expression and phosphorylation of MEK1/2 and ERK1/2 proteins in four breast cancer cell lines increased notably as compared with those in MCF-10 cells
2Serine PhosphorylationAlzheimer's diseaseUS22217064357
[Reference]: Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
3Serine PhosphorylationAlzheimer's diseaseUS22617064357
[Reference]: Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
NSCLC, melanoma
CTD (Curated)
(count: 5)		MESH:D003528 ; Carcinoma, Adenoid Cystic
MESH:C535579 ; Cardiofaciocutaneous syndrome
MESH:D056685 ; Costello Syndrome
MESH:D008545 ; Melanoma
MESH:D009634 ; Noonan Syndrome
GWASdb
(count: 2)		rs350897; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension
rs350896; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 21)
(view all)		 17        PALTINPTIAEGPSP     dbPAF
174       EEILGKVSIAVLRGL     dbPAF
198       MHRDVKPSNILVNSR     dbPAF
216       KLCDFGVSGQLIDSM     dbPAF
222       VSGQLIDSMANSFVG     dbPAF
226       LIDSMANSFVGTRSY     dbPAF
Acetylation
(count: 3)		 101       SGLIMARKLIHLEIK     PLMD
108       KLIHLEIKPAIRNQI     PLMD
361       PAERADLKMLTNHTF     PLMD
Ubiquitination
(count: 14)
(view all)		 101       SGLIMARKLIHLEIK     PLMD
108       KLIHLEIKPAIRNQI     PLMD
196       QIMHRDVKPSNILVN     PLMD
209       VNSRGEIKLCDFGVS     PLMD
352       FVNKCLIKNPAERAD     PLMD
361       PAERADLKMLTNHTF     PLMD
Sumoylation
(count: 1)		 108       KLIHLEIKPAIRNQI     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource