Tag | Content |
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UniProt Accession | VGFR2_HUMAN; P35968; |
Entrez ID | 3791 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) |
Gene Name | KDR; FLK1; VEGFR2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulato(view all) |
Sequence (Fasta) | MQSKVLLAVA LWLCVETRAA SVGLPSVSLD LPRLSIQKDI LTIKANTTLQ ITCRGQRDLD 60 WLWPNNQSGS EQRVEVTECS DGLFCKTLTI PKVIGNDTGA YKCFYRETDL ASVIYVYVQD 120 YRSPFIASVS DQHGVVYITE NKNKTVVIPC LGSISNLNVS LCARYPEKRF VPDGNRISWD 180 SKKGFTIPSY MISYAGMVFC EAKINDESYQ SIMYIVVVVG YRIYDVVLSP SHGIELSVGE 240 KLVLNCTART ELNVGIDFNW EYPSSKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDGVTRS 300 DQGLYTCAAS SGLMTKKNST FVRVHEKPFV AFGSGMESLV EATVGERVRI PAKYLGYPPP 360 EIKWYKNGIP LESNHTIKAG HVLTIMEVSE RDTGNYTVIL TNPISKEKQS HVVSLVVYVP 420 PQIGEKSLIS PVDSYQYGTT QTLTCTVYAI PPPHHIHWYW QLEEECANEP SQAVSVTNPY 480 PCEEWRSVED FQGGNKIEVN KNQFALIEGK NKTVSTLVIQ AANVSALYKC EAVNKVGRGE 540 RVISFHVTRG PEITLQPDMQ PTEQESVSLW CTADRSTFEN LTWYKLGPQP LPIHVGELPT 600 PVCKNLDTLW KLNATMFSNS TNDILIMELK NASLQDQGDY VCLAQDRKTK KRHCVVRQLT 660 VLERVAPTIT GNLENQTTSI GESIEVSCTA SGNPPPQIMW FKDNETLVED SGIVLKDGNR 720 NLTIRRVRKE DEGLYTCQAC SVLGCAKVEA FFIIEGAQEK TNLEIIILVG TAVIAMFFWL 780 LLVIILRTVK RANGGELKTG YLSIVMDPDE LPLDEHCERL PYDASKWEFP RDRLKLGKPL 840 GRGAFGQVIE ADAFGIDKTA TCRTVAVKML KEGATHSEHR ALMSELKILI HIGHHLNVVN 900 LLGACTKPGG PLMVIVEFCK FGNLSTYLRS KRNEFVPYKT KGARFRQGKD YVGAIPVDLK 960 RRLDSITSSQ SSASSGFVEE KSLSDVEEEE APEDLYKDFL TLEHLICYSF QVAKGMEFLA 1020 SRKCIHRDLA ARNILLSEKN VVKICDFGLA RDIYKDPDYV RKGDARLPLK WMAPETIFDR 1080 VYTIQSDVWS FGVLLWEIFS LGASPYPGVK IDEEFCRRLK EGTRMRAPDY TTPEMYQTML 1140 DCWHGEPSQR PTFSELVEHL GNLLQANAQQ DGKDYIVLPI SETLSMEEDS GLSLPTSPVS 1200 CMEEEEVCDP KFHYDNTAGI SQYLQNSKRK SRPVSVKTFE DIPLEEPEVK VIPDDNQTDS 1260 GMVLASEELK TLEDRTKLSP SFGGMVPSKS RESVASEGSN QTSGYQSGYH SDDTDTTVYS 1320 SEEAELLKLI EIGVQTGSTA QILQPDSGTT LSSPPV 1357 |
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Database | Annotation |
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Cancer Gene Census | NSCLC, angiosarcoma melanoma |
CTD (Curated) (count: 18) (view all) | MESH:D000230
; Adenocarcinoma MESH:D001943 ; Breast Neoplasms MESH:D002543 ; Cerebral Hemorrhage MESH:D015179 ; Colorectal Neoplasms MESH:D003928 ; Diabetic Nephropathies MESH:D004833 ; Epilepsy, Temporal Lobe |
DisGeNet (Curated) (count: 20) (view all) | C0001418; Adenocarcinoma
C0009404; Colorectal Neoplasms C0011881; Diabetic Nephropathy C0014556; Epilepsy, Temporal Lobe C0014859; Esophageal Neoplasms C0018923; Hemangiosarcoma |
HGMD (count: 6) | CE045735; Coronary artery lesions of Kawasaki disease, assoc.; Repeat variations
CM074307; Coronary heart disease, association with; Missense/nonsense CM074306; Coronary heart disease, association with; Missense/nonsense CM087498; Haemangioma, infantile; Missense/nonsense CR075254; Coronary heart disease, association with; Regulatory CR093046; Increased mRNA expression, association with ; Regulatory |
GWASdb (count: 7) (view all) | rs10008360; Bipolar disorder, affective; bipolar disorder
rs17085262; Coronary heart disease; coronary artery disease rs17710298; Suicide attempts in bipolar disorder; bipolar disorder rs2305949; Alcohol dependence; alcohol dependence rs7666097; LDL cholesterol; atherosclerosis|coronary artery disease rs7666097; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease |
PTM | Modification Sites |
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Phosphorylation (count: 23) (view all) | 1054 FGLARDIYKDPDYVR dbPAF
1059 DIYKDPDYVRKGDAR dbPAF 1175 AQQDGKDYIVLPISE dbPAF 1214 VCDPKFHYDNTAGIS dbPAF 1217 PKFHYDNTAGISQYL dbPAF 1223 NTAGISQYLQNSKRK dbPAF |
Acetylation (count: 1) | 826 RLPYDASKWEFPRDR PLMD |
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