P35611

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession ADDA_HUMAN; P35611;
Entrez ID 118
GenBank Protein ID NM_001119.4; NM_001286645.1; NM_014189.3; NM_014190.3; NM_176801.2; XM_005247937.2; XM_017007704.1; XM_017007706.1; XM_017007707.1; XM_017007708.1; XM_017007709.1; XM_017007710.1;
GenBank Nucleotide ID NP_001110.2; NP_001273574.1; NP_054908.2; NP_054909.2; NP_789771.1; XP_005247994.1; XP_016863193.1; XP_016863195.1; XP_016863196.1; XP_016863197.1; XP_016863198.1; XP_016863199.1;
Protein Name Alpha-adducin (Erythrocyte adducin subunit alpha)
Gene Name ADD1; ADDA
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMembrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Sequence
(Fasta)		MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN MMEQKKRVSM 60
ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT NVPNVYPAAP QGGMAALNMS 120
LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA AFYRLADLFG WSQLIYNHIT TRVNSEQEHF 180
LIVPFGLLYS EVTASSLVKI NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI 240
HTPAGAAVSA MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 300
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK AKSRSPGSPV 360
GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL REKSKKYSDV EVPASVTGYS 420
FASDGDSGTC SPLRHSFQKQ QREKTRWLNS GRGDEASEEG QNGSSPKSKT KWTKEDGHRT 480
STSAVPNLFV PLNTNPKEVQ EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT 540
ASKAIIEKEY QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS 600
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS EALGFPMLEK 660
EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG AAADPGSDGS PGKSPSKKKK 720
KFRTPSFLKK SKKKSDS 738

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationNon-cardia gastric cancerCS58623985264
[Reference]: Fnnctional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D006973 ; Hypertension
DisGeNet (Curated)
(count: 3)		C0020538; Hypertensive disease
C0085580; Essential Hypertension
C2239176; Liver carcinoma
HGMD
(count: 1)		CM021240; Hypertension, association with; Missense/nonsense
GWASdb
(count: 14)
(view all)		rs624833; Stroke; cerebrovascular disease
rs10488838; Alcohol consumption; alcohol abuse|alcohol dependence
rs3775068; Coronary heart disease; coronary artery disease
rs3775068; Cognitive impairment induced by topiramate; cognitive disorder
rs17777307; Multiple complex diseases; Null
rs2285084; Birth weight; end stage renal failure|type 2 diabetes mellitus|cardiovascular system disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 59)
(view all)		 11        DSRAAVVTSPPPTTA     dbPAF
12        SRAAVVTSPPPTTAP     dbPAF
16        VVTSPPPTTAPHKER     dbPAF
17        VTSPPPTTAPHKERY     dbPAF
24        TAPHKERYFDRVDEN     dbPAF
331       ACEIQVRTLASAGGP     dbPAF
Acetylation
(count: 3)		 140       SDSIAYDKGEKLLRC     PLMD
143       IAYDKGEKLLRCKLA     PLMD
543       GELVTASKAIIEKEY     PLMD
Ubiquitination
(count: 13)
(view all)		 140       SDSIAYDKGEKLLRC     PLMD
143       IAYDKGEKLLRCKLA     PLMD
148       GEKLLRCKLAAFYRL     PLMD
21        PPTTAPHKERYFDRV     PLMD
288       EEKVLIQKNLGPKSK     PLMD
348       LVLLNPEKYKAKSRS     PLMD
Glycation
(count: 3)		 140       SDSIAYDKGEKLLRC     PLMD
143       IAYDKGEKLLRCKLA     PLMD
235       YAARPDVKCVVHIHT     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource