Tag | Content |
---|---|
UniProt Accession | MYH10_HUMAN; P35580; |
Entrez ID | 4628 |
GenBank Protein ID | NM_001256012.1; NM_001256095.1; NM_005964.3; XM_017024680.1; XM_017024681.1; XM_017024682.1; |
GenBank Nucleotide ID | NP_001242941.1; NP_001243024.1; NP_005955.3; XP_016880169.1; XP_016880170.1; XP_016880171.1; |
Protein Name | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) |
Gene Name | MYH10 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. |
Sequence (Fasta) | MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 60 ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 120 FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 180 GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 240 RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 300 LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 360 FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 420 VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 480 EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 540 FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 600 DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES 660 LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV 720 FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE 780 ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK 840 VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET 900 ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD 960 EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE 1020 KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE 1080 LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ 1140 KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR 1200 HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ 1260 VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT 1320 QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV 1380 DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR 1440 QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE 1500 EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED 1560 AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK 1620 KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK 1680 KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ 1740 LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK 1800 LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED 1860 ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE 1920 VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE 1977 |
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Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D005923 ; Glomerulosclerosis, Focal Segmental |
GWASdb (count: 3) | rs111570631; Breast cancer (ER positive); breast cancer
rs904417; Multiple complex diseases; Null rs7208821; Alcohol dependence; alcohol dependence |
PTM | Modification Sites |
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Phosphorylation (count: 60) (view all) | 1013 DRIAECSSQLAEEEE dbPAF
1037 NKQEVMISDLEERLK dbPAF 1145 EKQKRDLSEELEALK dbPAF 1153 EELEALKTELEDTLD dbPAF 1158 LKTELEDTLDTTAAQ dbPAF 1161 ELEDTLDTTAAQQEL dbPAF |
Acetylation (count: 39) (view all) | 1021 QLAEEEEKAKNLAKI PLMD
106 ASVLHNLKDRYYSGL PLMD 1188 KALEEETKNHEAQIQ PLMD 1216 SEQLEQAKRFKANLE PLMD 1234 QGLETDNKELACEVK PLMD 1241 KELACEVKVLQQVKA PLMD |
Ubiquitination (count: 38) (view all) | 1021 QLAEEEEKAKNLAKI PLMD
1031 NLAKIRNKQEVMISD PLMD 1044 SDLEERLKKEEKTRQ PLMD 1106 GDDETLHKNNALKVV PLMD 1131 QEDFESEKASRNKAE PLMD 1181 QEVAELKKALEEETK PLMD |
Glycation (count: 1) | 1181 QEVAELKKALEEETK PLMD |
Malonylation (count: 9) (view all) | 1021 QLAEEEEKAKNLAKI PLMD
1219 LEQAKRFKANLEKNK PLMD 1241 KELACEVKVLQQVKA PLMD 1256 ESEHKRKKLDAQVQE PLMD 1645 KARDEVIKQLRKLQA PLMD 1800 QNKELKAKLQELEGA PLMD |
Methylation (count: 1) | 594 KADEWLMKNMDPLND PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |