P35580

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession MYH10_HUMAN; P35580;
Entrez ID 4628
GenBank Protein ID NM_001256012.1; NM_001256095.1; NM_005964.3; XM_017024680.1; XM_017024681.1; XM_017024682.1;
GenBank Nucleotide ID NP_001242941.1; NP_001243024.1; NP_005955.3; XP_016880169.1; XP_016880170.1; XP_016880171.1;
Protein Name Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)
Gene Name MYH10
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.
Sequence
(Fasta)
MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI KEERGDEVMV 60
ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLKDRYY SGLIYTYSGL 120
FCVVINPYKN LPIYSENIIE MYRGKKRHEM PPHIYAISES AYRCMLQDRE DQSILCTGES 180
GAGKTENTKK VIQYLAHVAS SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS 240
RFGKFIRINF DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL 300
LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV SSVLQFGNIS 360
FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR IKVGRDYVQK AQTKEQADFA 420
VEALAKATYE RLFRWLVHRI NKALDRTKRQ GASFIGILDI AGFEIFELNS FEQLCINYTN 480
EKLQQLFNHT MFILEQEEYQ REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW 540
FPKATDKTFV EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN 600
DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF RTVGQLYKES 660
LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR CNGVLEGIRI CRQGFPNRIV 720
FQEFRQRYEI LTPNAIPKGF MDGKQACERM IRALELDPNL YRIGQSKIFF RAGVLAHLEE 780
ERDLKITDII IFFQAVCRGY LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK 840
VKPLLQVTRQ EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET 900
ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA HIQDLEEQLD 960
EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE KKLMEDRIAE CSSQLAEEEE 1020
KAKNLAKIRN KQEVMISDLE ERLKKEEKTR QELEKAKRKL DGETTDLQDQ IAELQAQIDE 1080
LKLQLAKKEE ELQGALARGD DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ 1140
KRDLSEELEA LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKNH EAQIQDMRQR 1200
HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES EHKRKKLDAQ 1260
VQELHAKVSE GDRLRVELAE KASKLQNELD NVSTLLEEAE KKGIKFAKDA ASLESQLQDT 1320
QELLQEETRQ KLNLSSRIRQ LEEEKNSLQE QQEEEEEARK NLEKQVLALQ SQLADTKKKV 1380
DDDLGTIESL EEAKKKLLKD AEALSQRLEE KALAYDKLEK TKNRLQQELD DLTVDLDHQR 1440
QVASNLEKKQ KKFDQLLAEE KSISARYAEE RDRAEAEARE KETKALSLAR ALEEALEAKE 1500
EFERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE LEDELQATED 1560
AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE LEAELEDERK QRALAVASKK 1620
KMEIDLKDLE AQIEAANKAR DEVIKQLRKL QAQMKDYQRE LEEARASRDE IFAQSKESEK 1680
KLKSLEAEIL QLQEELASSE RARRHAEQER DELADEITNS ASGKSALLDE KRRLEARIAQ 1740
LEEELEEEQS NMELLNDRFR KTTLQVDTLN AELAAERSAA QKSDNARQQL ERQNKELKAK 1800
LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK LKEIFMQVED 1860
ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR RKLQRELDDA TEANEGLSRE 1920
VSTLKNRLRR GGPISFSSSR SGRRQLHLEG ASLELSDDDT ESKTSDVNET QPPQSE 1977

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationNeuroblastomaUY141524349301
[Reference]: increased in NB10 cells (MYCN amplified neuroblastoma line) compared to NPC cells (normal neural crest line)

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)
MESH:D005923 ; Glomerulosclerosis, Focal Segmental
GWASdb
(count: 3)
rs111570631; Breast cancer (ER positive); breast cancer
rs904417; Multiple complex diseases; Null
rs7208821; Alcohol dependence; alcohol dependence

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 60)
(view all)
1013      DRIAECSSQLAEEEE     dbPAF
1037      NKQEVMISDLEERLK     dbPAF
1145      EKQKRDLSEELEALK     dbPAF
1153      EELEALKTELEDTLD     dbPAF
1158      LKTELEDTLDTTAAQ     dbPAF
1161      ELEDTLDTTAAQQEL     dbPAF
Acetylation
(count: 39)
(view all)
1021      QLAEEEEKAKNLAKI     PLMD
106       ASVLHNLKDRYYSGL     PLMD
1188      KALEEETKNHEAQIQ     PLMD
1216      SEQLEQAKRFKANLE     PLMD
1234      QGLETDNKELACEVK     PLMD
1241      KELACEVKVLQQVKA     PLMD
Ubiquitination
(count: 38)
(view all)
1021      QLAEEEEKAKNLAKI     PLMD
1031      NLAKIRNKQEVMISD     PLMD
1044      SDLEERLKKEEKTRQ     PLMD
1106      GDDETLHKNNALKVV     PLMD
1131      QEDFESEKASRNKAE     PLMD
1181      QEVAELKKALEEETK     PLMD
Glycation
(count: 1)
1181      QEVAELKKALEEETK     PLMD
Malonylation
(count: 9)
(view all)
1021      QLAEEEEKAKNLAKI     PLMD
1219      LEQAKRFKANLEKNK     PLMD
1241      KELACEVKVLQQVKA     PLMD
1256      ESEHKRKKLDAQVQE     PLMD
1645      KARDEVIKQLRKLQA     PLMD
1800      QNKELKAKLQELEGA     PLMD
Methylation
(count: 1)
594       KADEWLMKNMDPLND     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource