| Tag | Content |
|---|---|
| UniProt Accession | IRS1_HUMAN; P35568; |
| Entrez ID | 3667 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Insulin receptor substrate 1 (IRS-1) |
| Gene Name | IRS1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). |
| Sequence (Fasta) | MASPPESDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP 60 KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKGH 120 HDGAAALGAG GGGGSCSGSS GLGEAGEDLS YGDVPPGPAF KEVWQVILKP KGLGQTKNLI 180 GIYRLCLTSK TISFVKLNSE AAAVVLQLMN IRRCGHSENF FFIEVGRSAV TGPGEFWMQV 240 DDSVVAQNMH ETILEAMRAM SDEFRPRSKS QSSSNCSNPI SVPLRRHHLN NPPPSQVGLT 300 RRSRTESITA TSPASMVGGK PGSFRVRASS DGEGTMSRPA SVDGSPVSPS TNRTHAHRHR 360 GSARLHPPLN HSRSIPMPAS RCSPSATSPV SLSSSSTSGH GSTSDCLFPR RSSASVSGSP 420 SDGGFISSDE YGSSPCDFRS SFRSVTPDSL GHTPPARGEE ELSNYICMGG KGPSTLTAPN 480 GHYILSRGGN GHRCTPGTGL GTSPALAGDE AASAADLDNR FRKRTHSAGT SPTITHQKTP 540 SQSSVASIEE YTEMMPAYPP GGGSGGRLPG HRHSAFVPTR SYPEEGLEMH PLERRGGHHR 600 PDSSTLHTDD GYMPMSPGVA PVPSGRKGSG DYMPMSPKSV SAPQQIINPI RRHPQRVDPN 660 GYMMMSPSGG CSPDIGGGPS SSSSSSNAVP SGTSYGKLWT NGVGGHHSHV LPHPKPPVES 720 SGGKLLPCTG DYMNMSPVGD SNTSSPSDCY YGPEDPQHKP VLSYYSLPRS FKHTQRPGEP 780 EEGARHQHLR LSTSSGRLLY AATADDSSSS TSSDSLGGGY CGARLEPSLP HPHHQVLQPH 840 LPRKVDTAAQ TNSRLARPTR LSLGDPKAST LPRAREQQQQ QQPLLHPPEP KSPGEYVNIE 900 FGSDQSGYLS GPVAFHSSPS VRCPSQLQPA PREEETGTEE YMKMDLGPGR RAAWQESTGV 960 EMGRLGPAPP GAASICRPTR AVPSSRGDYM TMQMSCPRQS YVDTSPAAPV SYADMRTGIA 1020 AEEVSLPRAT MAAASSSSAA SASPTGPQGA AELAAHSSLL GGPQGPGGMS AFTRVNLSPN 1080 RNQSAKVIRA DPQGCRRRHS SETFSSTPSA TRVGNTVPFG AGAAVGGGGG SSSSSEDVKR 1140 HSSASFENVW LRPGELGGAP KEPAKLCGAA GGLENGLNYI DLDLVKDFKQ CPQECTPEPQ 1200 PPPPPPPHQP LGSGESSSTR RSSEDLSAYA SISFQKQPED RQ 1243 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 13) (view all) | MESH:D006528
; Carcinoma, Hepatocellular MESH:D002471 ; Cell Transformation, Neoplastic MESH:D003324 ; Coronary Artery Disease MESH:D003327 ; Coronary Disease MESH:D003920 ; Diabetes Mellitus MESH:D003921 ; Diabetes Mellitus, Experimental |
| DisGeNet (Curated) (count: 12) (view all) | C0007621; Neoplastic Cell Transformation
C0011849; Diabetes Mellitus C0011853; Diabetes Mellitus, Experimental C0011860; Diabetes Mellitus, Non-Insulin-Dependent C0020459; Hyperinsulinism C0020473; Hyperlipidemia |
| HGMD (count: 18) (view all) | CD951753; Diabetes, NIDDM, susceptibility to; Small deletions
CD962050; Diabetes, NIDDM; Small deletions CM004557; Diabetes, NIDDM, association with; Missense/nonsense CM930443; Diabetes, NIDDM, association with; Missense/nonsense CM030892; Diabetes mellitus, type 2; Missense/nonsense CM981070; Diabetes, NIDDM; Missense/nonsense |
| GWASdb (count: 13) (view all) | rs2288587; Multiple complex diseases; Null
rs16822570; Multiple complex diseases; Null rs10182336; Coronary artery calcification; coronary artery disease rs13431179; Multiple complex diseases; Null rs13431179; Sudden cardiac arrest; coronary artery disease rs10205233; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 129) (view all) | 1005 RQSYVDTSPAAPVSY dbPAF
1011 TSPAAPVSYADMRTG dbPAF 1012 SPAAPVSYADMRTGI dbPAF 1041 ASSSSAASASPTGPQ dbPAF 1043 SSSAASASPTGPQGA dbPAF 1078 AFTRVNLSPNRNQSA dbPAF |
| Acetylation (count: 2) | 52 EYYENEKKWRHKSSA PLMD
61 RHKSSAPKRSIPLES PLMD |
| Ubiquitination (count: 1) | 867 RLSLGDPKASTLPRA PLMD |
| Glycation (count: 2) | 56 NEKKWRHKSSAPKRS PLMD
844 LQPHLPRKVDTAAQT PLMD |