| Tag | Content |
|---|---|
| UniProt Accession | PGH2_HUMAN; P35354; |
| Entrez ID | 5743 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) |
| Gene Name | PTGS2; COX2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. |
| Sequence (Fasta) | MLARALLLCA VLALSHTANP CCSHPCQNRG VCMSVGFDQY KCDCTRTGFY GENCSTPEFL 60 TRIKLFLKPT PNTVHYILTH FKGFWNVVNN IPFLRNAIMS YVLTSRSHLI DSPPTYNADY 120 GYKSWEAFSN LSYYTRALPP VPDDCPTPLG VKGKKQLPDS NEIVEKLLLR RKFIPDPQGS 180 NMMFAFFAQH FTHQFFKTDH KRGPAFTNGL GHGVDLNHIY GETLARQRKL RLFKDGKMKY 240 QIIDGEMYPP TVKDTQAEMI YPPQVPEHLR FAVGQEVFGL VPGLMMYATI WLREHNRVCD 300 VLKQEHPEWG DEQLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE LLFNKQFQYQ 360 NRIAAEFNTL YHWHPLLPDT FQIHDQKYNY QQFIYNNSIL LEHGITQFVE SFTRQIAGRV 420 AGGRNVPPAV QKVSQASIDQ SRQMKYQSFN EYRKRFMLKP YESFEELTGE KEMSAELEAL 480 YGDIDAVELY PALLVEKPRP DAIFGETMVE VGAPFSLKGL MGNVICSPAY WKPSTFGGEV 540 GFQIINTASI QSLICNNVKG CPFTSFSVPD PELIKTVTIN ASSSRSGLDD INPTVLLKER 600 STEL 605 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 105) (view all) | MESH:D000230
; Adenocarcinoma MESH:C562730 ; Adenocarcinoma Of Esophagus MESH:D011125 ; Adenomatous Polyposis Coli MESH:D000310 ; Adrenal Gland Neoplasms MESH:D000419 ; Albuminuria MESH:D000690 ; Amyotrophic Lateral Sclerosis |
| GWASdb (count: 5) | rs4648310; Blood pressure; hypertension
rs2206593; Serum alpha1-antitrypsin levels; chronic obstructive pulmonary disease rs5275; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension rs2745557; Serum alpha1-antitrypsin levels; chronic obstructive pulmonary disease rs20417; Drug response to Rofecoxib; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 2) | 120 PPTYNADYGYKSWEA dbPAF
446 DQSRQMKYQSFNEYR dbPAF |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |