| Tag | Content |
|---|---|
| UniProt Accession | PTN11_MOUSE; P35235; |
| Entrez ID | 19247 |
| GenBank Protein ID | NM_001109992.1; NM_011202.3; |
| GenBank Nucleotide ID | NP_001103462.1; NP_035332.1; |
| Protein Name | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2) |
| Gene Name | Ptpn11 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. |
| Sequence (Fasta) | MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 60 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 120 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD 180 VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 240 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 360 ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQAL LQGNTERTVW 420 QYHFRTWPDH GVPSDPGGVL DFLEEVHHKQ ESIVDAGPVV VHCSAGIGRT GTFIVIDILI 480 DIIREKGVDC DIDVPKTIQM VRSQRSGMVQ TEAQYRFIYM AVQHYIETLQ RRIEEEQKSK 540 RKGHEYTNIK YSLVDQTSGD QSPLPPCTPT PPCAEMREDS ARVYENVGLM QQQRSFR 598 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 16) (view all) | MESH:D000230
; Adenocarcinoma MESH:D001254 ; Astrocytoma MESH:D002294 ; Carcinoma, Squamous Cell MESH:C535579 ; Cardiofaciocutaneous syndrome MESH:D056685 ; Costello Syndrome MESH:D004687 ; Enchondromatosis |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 17) (view all) | 142 FLVRESQSHPGDFVL dbPAF
279 ENKNKNRYKNILPFD dbPAF 304 PNEPVSDYINANIIM dbPAF 327 NSKPKKSYIATQGCL dbPAF 34 GSFLARPSKSNPGDF dbPAF 36 FLARPSKSNPGDFTL dbPAF |
| Acetylation (count: 3) | 198 TDLVEHYKKNPMVET PLMD
358 RVIVMTTKEVERGKS PLMD 486 LIDIIREKGVDCDID PLMD |
| Ubiquitination (count: 1) | 91 HHGQLKEKNGDVIEL PLMD |
| Malonylation (count: 2) | 131 KLLTEKGKHGSFLVR PLMD
280 NKNKNRYKNILPFDH PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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