| Tag | Content |
|---|---|
| UniProt Accession | CTNB1_HUMAN; P35222; |
| Entrez ID | 1499 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Catenin beta-1 (Beta-catenin) |
| Gene Name | CTNNB1; CTNNB; OK/SW-cl.35; PRO2286 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adh(view all) |
| Sequence (Fasta) | MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS 60 QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT 120 NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 180 KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 240 VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300 LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA 360 GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 420 AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 480 AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 540 VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 600 QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 660 RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEPLGYR QDDPSYRSFH 720 SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD 780 L 782 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | colorectal, ovarian, hepatoblastoma, pleomorphic salivary gland adenoma, other tumour types |
| CTD (Curated) (count: 42) (view all) | MESH:D058739
; Aberrant Crypt Foci MESH:D000015 ; Abnormalities, Multiple MESH:D000230 ; Adenocarcinoma MESH:D000236 ; Adenoma MESH:D018248 ; Adenoma, Liver Cell MESH:D000310 ; Adrenal Gland Neoplasms |
| DisGeNet (Curated) (count: 106) (view all) | C0000737; Abdominal Pain
C0001418; Adenocarcinoma C0001430; Adenoma C0001624; Adrenal Gland Neoplasms C0007134; Renal Cell Carcinoma C0007528; Cecal Neoplasms |
| HGMD (count: 1) | CM043757; Colorectal adenoma?; Missense/nonsense
|
| GWASdb (count: 1) | rs13072632; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 49) (view all) | 102 RAAMFPETLDEGMQI dbPAF
112 EGMQIPSTQFDAAHP dbPAF 120 QFDAAHPTNVQRLAE dbPAF 142 AVVNLINYQDDAELA dbPAF 179 AVMVHQLSKKEASRH dbPAF 191 SRHAIMRSPQMVSAI dbPAF |
| Acetylation (count: 5) | 133 AEPSQMLKHAVVNLI PLMD
19 MAMEPDRKAAVSHWQ PLMD 345 WTTSRVLKVLSVCSS PLMD 354 LSVCSSNKPAIVEAG PLMD 49 TAPSLSGKGNPEEED PLMD |
| Ubiquitination (count: 17) (view all) | 133 AEPSQMLKHAVVNLI PLMD
158 RAIPELTKLLNDEDQ PLMD 170 EDQVVVNKAAVMVHQ PLMD 180 VMVHQLSKKEASRHA PLMD 181 MVHQLSKKEASRHAI PLMD 19 MAMEPDRKAAVSHWQ PLMD |