| Tag | Content |
|---|---|
| UniProt Accession | GPC1_RAT; P35053; |
| Entrez ID | 58920 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Glypican-1 (HSPG M12) [Cleaved into: Secreted glypican-1] |
| Gene Name | Gpc1 |
| Organism | Rattus norvegicus |
| NCBI Taxa ID | 10116 |
| Functional Description | Cell surface proteoglycan that bears heparan sulfate. May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Binds Cu(2+) or Zn(2+) ions (By similarity). Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination. |
| Sequence (Fasta) | MELRARGWWL LCAAAALVAC TRGDPASKSR SCSEVRQIYG AKGFSLSDVP QAEISGEHLR 60 ICPQGYTCCT SEMEENLANH SRMELETALH DSSRALQATL ATQLHGIDDH FQRLLNDSER 120 TLQDAFPGAF GDLYTQNTRA FRDLYAELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP 180 QLLLPDDYLD CLGKQAEALR PFGDAPRELR LRATRAFVAA RSFVQGLGVA SDVVRKVAQV 240 PLAPECSRAV MKLVYCAHCR GVPGARPCPD YCRNVLKGCL ANQADLDAEW RNLLDSMVLI 300 TDKFWGPSGA EYVIGSVHMW LAEAINALQD NKDTLTAKVI QGCGNPKVNP HGSGPEEKRR 360 RAKLALQEKS STGTLEKLVS EAKAQLRDIQ DYWISLPGTL CSEKMAMSPA SDDRCWNGIS 420 KGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRGA YGGNDVDFQD 480 ASDDGSGSGS GGGCPDDACG RRVSKKSSSS RTPLIHALPG LSEQEGQKTS AATRPEPHYF 540 FLLFLFTLVL AAARPRWR 559 |
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| PTM | Modification Sites |
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