P34741

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SDC2_HUMAN; P34741;
Entrez ID 6383
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)
Gene Name SDC2; HSPG1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).
Sequence
(Fasta)		MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD YASASGSGAD 60
EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ TKSPEETDKE KVHLSDSERK 120
MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI AGGVIGFLFA IFLILLLVYR MRKKDEGSYD 180
LGERKPSSAA YQKAPTKEFY A 202

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationNeuroblastomaUY19124349301
[Reference]: Increased in NB10 cells (MYCN amplified neuroblastoma line) compared to NPC cells (normal neural crest line)

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 21)
(view all)		rs2582814; Stroke; cerebrovascular disease
rs2589183; Chronic obstructive pulmonary disease; chronic obstructive pulmonary disease
rs6985568; Multiple complex diseases; Null
rs6985568; Lipoproteins; lipid metabolism disorder|cardiovascular system disease|obesity
rs2439523; Response to lithium treatment in bipolar disorder; bipolar disorder
rs874644; Urinary metabolites; kidney disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 9)
(view all)		 115       DKEKVHLSDSERKMD     dbPAF
178       MRKKDEGSYDLGERK     dbPAF
179       RKKDEGSYDLGERKP     dbPAF
187       DLGERKPSSAAYQKA     dbPAF
188       LGERKPSSAAYQKAP     dbPAF
191       RKPSSAAYQKAPTKE     dbPAF
Ubiquitination
(count: 3)		 185       SYDLGERKPSSAAYQ     PLMD
193       PSSAAYQKAPTKEFY     PLMD
197       AYQKAPTKEFYA***     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource