P34080

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession AQP2_RAT; P34080;
Entrez ID 25386
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)
Gene Name Aqp2
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionForms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Sequence
(Fasta)		MWELRSIAFS RAVLAEFLAT LLFVFFGLGS ALQWASSPPS VLQIAVAFGL GIGILVQALG 60
HVSGAHINPA VTVACLVGCH VSFLRAAFYV AAQLLGAVAG AAILHEITPV EIRGDLAVNA 120
LHNNATAGQA VTVELFLTMQ LVLCIFASTD ERRGDNLGSP ALSIGFSVTL GHLLGIYFTG 180
CSMNPARSLA PAVVTGKFDD HWVFWIGPLV GAIIGSLLYN YLLFPSAKSL QERLAVLKGL 240
EPDTDWEERE VRRRQSVELH SPQSLPRGSK A 272

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationDiabetes mellitusUS25618029369
[Reference]: We demonstrated that the protein expression of renal AQP2, Ser-256 phosphorylated AQP2, AQP3, beta- and gamma-ENaC (but not alpha-ENaC) increased consistently with an increased AVP response.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D009202 ; Cardiomyopathies
MESH:D018500 ; Diabetes Insipidus, Nephrogenic

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 4)		 256       REVRRRQSVELHSPQ     dbPAF
261       RQSVELHSPQSLPRG     dbPAF
264       VELHSPQSLPRGSKA     dbPAF
269       PQSLPRGSKA*****     dbPAF