| Tag | Content |
|---|---|
| UniProt Accession | MCM7_HUMAN; P33993; |
| Entrez ID | 4176 |
| GenBank Protein ID | NM_001278595.1; NM_005916.4; NM_182776.2; |
| GenBank Nucleotide ID | NP_001265524.1; NP_005907.3; NP_877577.1; |
| Protein Name | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) |
| Gene Name | MCM7; CDC47; MCM2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. |
| Sequence (Fasta) | MALKDYALEK EKVKKFLQEF YQDDELGKKQ FKYGNQLVRL AHREQVALYV DLDDVAEDDP 60 ELVDSICENA RRYAKLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGMVR 120 SPQNQYPAEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPKMVVA 180 TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSRFI KFQEMKMQEH 240 SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQVVQ GLLSETYLEA 300 HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV KKALLLLLVG 360 GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR 420 DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA 480 RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV 540 HQHSRQPPSQ FEPLDMKLMR RYIAMCREKQ PMVPESLADY ITAAYVEMRR EAWASKDATY 600 TSARTLLAIL RLSTALARLR MVDVVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV 660 IFATVRELVS GGRSVRFSEA EQRCVSRGFT PAQFQAALDE YEELNVWQVN ASRTRITFV 720 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 3) | rs2261360; Interstitial lung disease; interstitial lung disease
rs13242458; Dehydroepiandrosterone sulphate levels; adrenal gland disease rs139603502; Prostate cancer (advanced); prostate cancer |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 26) (view all) | 113 RLMMEQRSRDPGMVR dbPAF
121 RDPGMVRSPQNQYPA dbPAF 168 VTVRGIVTRVSEVKP dbPAF 309 RIVKMNKSEDDESGA dbPAF 314 NKSEDDESGAGELTR dbPAF 320 ESGAGELTREELRQI dbPAF |
| Acetylation (count: 10) (view all) | 159 VRADSVGKLVTVRGI PLMD
236 FIKFQEMKMQEHSDQ PLMD 28 YQDDELGKKQFKYGN PLMD 308 HRIVKMNKSEDDESG PLMD 351 IYGHEDVKKALLLLL PLMD 4 ****MALKDYALEKE PLMD |
| Ubiquitination (count: 29) (view all) | 10 LKDYALEKEKVKKFL PLMD
12 DYALEKEKVKKFLQE PLMD 14 ALEKEKVKKFLQEFY PLMD 145 FQGPSSNKPRVIREV PLMD 15 LEKEKVKKFLQEFYQ PLMD 159 VRADSVGKLVTVRGI PLMD |
| Sumoylation (count: 15) (view all) | 10 LKDYALEKEKVKKFL PLMD
15 LEKEKVKKFLQEFYQ PLMD 159 VRADSVGKLVTVRGI PLMD 174 VTRVSEVKPKMVVAT PLMD 231 TRGSRFIKFQEMKMQ PLMD 236 FIKFQEMKMQEHSDQ PLMD |
| Methylation (count: 1) | 449 CCIDEFDKMAEADRT PLMD |
| Succinylation (count: 3) | 10 LKDYALEKEKVKKFL PLMD
351 IYGHEDVKKALLLLL PLMD 4 ****MALKDYALEKE PLMD |