| Tag | Content |
|---|---|
| UniProt Accession | H2B1B_HUMAN; P33778; |
| Entrez ID | 3018 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Histone H2B type 1-B (Histone H2B.1) (Histone H2B.f) (H2B/f) |
| Gene Name | HIST1H2BB; H2BFF |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Sequence (Fasta) | MPEPSKSAPA PKKGSKKAIT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM 60 GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT 120 KYTSSK 127 |
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| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 11) (view all) | 116 KHAVSEGTKAVTKYT dbPAF
120 SEGTKAVTKYTSSK* dbPAF 15 APAPKKGSKKAITKA dbPAF 33 DGKKRKRSRKESYSI dbPAF 37 RKRSRKESYSIYVYK dbPAF 38 KRSRKESYSIYVYKV dbPAF |
| Acetylation (count: 7) (view all) | 12 SKSAPAPKKGSKKAI PLMD
13 KSAPAPKKGSKKAIT PLMD 16 PAPKKGSKKAITKAQ PLMD 17 APKKGSKKAITKAQK PLMD 21 GSKKAITKAQKKDGK PLMD 24 KAITKAQKKDGKKRK PLMD |
| Ubiquitination (count: 1) | 6 **MPEPSKSAPAPKK PLMD |
| Butyrylation (count: 6) | 12 SKSAPAPKKGSKKAI PLMD
13 KSAPAPKKGSKKAIT PLMD 16 PAPKKGSKKAITKAQ PLMD 17 APKKGSKKAITKAQK PLMD 21 GSKKAITKAQKKDGK PLMD 6 **MPEPSKSAPAPKK PLMD |
| Crotonylation (count: 8) (view all) | 12 SKSAPAPKKGSKKAI PLMD
13 KSAPAPKKGSKKAIT PLMD 16 PAPKKGSKKAITKAQ PLMD 17 APKKGSKKAITKAQK PLMD 21 GSKKAITKAQKKDGK PLMD 24 KAITKAQKKDGKKRK PLMD |