Tag | Content |
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UniProt Accession | OPRM_RAT; P33535; |
Entrez ID | 25601 |
GenBank Protein ID | NM_001038597.2; NM_001038599.2; NM_001038600.2; NM_001038601.2; NM_001304735.1; NM_001304737.1; NM_001304738.1; NM_001304740.1; NM_013071.2; |
GenBank Nucleotide ID | NP_001033686.1; NP_001033688.2; NP_001033689.1; NP_001033690.1; NP_001291664.1; NP_001291666.1; NP_001291667.1; NP_001291669.1; NP_037203.1; |
Protein Name | Mu-type opioid receptor (M-OR-1) (MOR-1) (Opioid receptor B) |
Gene Name | Oprm1; Ror-b |
Organism | Rattus norvegicus |
NCBI Taxa ID | 10116 |
Functional Description | Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agon(view all) |
Sequence (Fasta) | MDSSTGPGNT SDCSDPLAQA SCSPAPGSWL NLSHVDGNQS DPCGLNRTGL GGNDSLCPQT 60 GSPSMVTAIT IMALYSIVCV VGLFGNFLVM YVIVRYTKMK TATNIYIFNL ALADALATST 120 LPFQSVNYLM GTWPFGTILC KIVISIDYYN MFTSIFTLCT MSVDRYIAVC HPVKALDFRT 180 PRNAKIVNVC NWILSSAIGL PVMFMATTKY RQGSIDCTLT FSHPTWYWEN LLKICVFIFA 240 FIMPVLIITV CYGLMILRLK SVRMLSGSKE KDRNLRRITR MVLVVVAVFI VCWTPIHIYV 300 IIKALITIPE TTFQTVSWHF CIALGYTNSC LNPVLYAFLD ENFKRCFREF CIPTSSTIEQ 360 QNSTRVRQNT REHPSTANTV DRTNHQLENL EAETAPLP 399 |
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Database | Annotation |
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CTD (Curated) (count: 20) (view all) | MESH:D000437
; Alcoholism MESH:D019969 ; Amphetamine-Related Disorders MESH:D019970 ; Cocaine-Related Disorders MESH:D003248 ; Constipation MESH:D020820 ; Dyskinesias MESH:D004827 ; Epilepsy |
PTM | Modification Sites |
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Phosphorylation (count: 15) (view all) | 101 VRYTKMKTATNIYIF dbPAF
103 YTKMKTATNIYIFNL dbPAF 106 MKTATNIYIFNLALA dbPAF 166 CTMSVDRYIAVCHPV dbPAF 180 VKALDFRTPRNAKIV dbPAF 261 LMILRLKSVRMLSGS dbPAF |