| Tag | Content |
|---|---|
| UniProt Accession | CADH5_HUMAN; P33151; |
| Entrez ID | 1003 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) |
| Gene Name | CDH5 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. |
| Sequence (Fasta) | MQRLMMLLAT SGACLGLLAV AAVAAAGANP AQRDTHSLLP THRRQKRDWI WNQMHIDEEK 60 NTSLPHHVGK IKSSVSRKNA KYLLKGEYVG KVFRVDAETG DVFAIERLDR ENISEYHLTA 120 VIVDKDTGEN LETPSSFTIK VHDVNDNWPV FTHRLFNASV PESSAVGTSV ISVTAVDADD 180 PTVGDHASVM YQILKGKEYF AIDNSGRIIT ITKSLDREKQ ARYEIVVEAR DAQGLRGDSG 240 TATVLVTLQD INDNFPFFTQ TKYTFVVPED TRVGTSVGSL FVEDPDEPQN RMTKYSILRG 300 DYQDAFTIET NPAHNEGIIK PMKPLDYEYI QQYSFIVEAT DPTIDLRYMS PPAGNRAQVI 360 INITDVDEPP IFQQPFYHFQ LKENQKKPLI GTVLAMDPDA ARHSIGYSIR RTSDKGQFFR 420 VTKKGDIYNE KELDREVYPW YNLTVEAKEL DSTGTPTGKE SIVQVHIEVL DENDNAPEFA 480 KPYQPKVCEN AVHGQLVLQI SAIDKDITPR NVKFKFILNT ENNFTLTDNH DNTANITVKY 540 GQFDREHTKV HFLPVVISDN GMPSRTGTST LTVAVCKCNE QGEFTFCEDM AAQVGVSIQA 600 VVAILLCILT ITVITLLIFL RRRLRKQARA HGKSVPEIHE QLVTYDEEGG GEMDTTSYDV 660 SVLNSVRRGG AKPPRPALDA RPSLYAQVQK PPRHAPGAHG GPGEMAAMIE VKKDEADHDG 720 DGPPYDTLHI YGYEGSESIA ESLSSLGTDS SDSDVDYDFL NDWGPRFKML AELYGSDPRE 780 ELLY 785 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 5) | MESH:D001943
; Breast Neoplasms MESH:D015179 ; Colorectal Neoplasms MESH:D008105 ; Liver Cirrhosis, Biliary MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D054318 ; No-Reflow Phenomenon |
| DisGeNet (Curated) (count: 6) | C0001973; Alcoholic Intoxication, Chronic
C0009404; Colorectal Neoplasms C0023892; Biliary cirrhosis C0023893; Liver Cirrhosis, Experimental C0232347; No-Reflow Phenomenon C1458155; Mammary Neoplasms |
| GWASdb (count: 5) | rs1076020; Urinary metabolites; kidney disease
rs1076019; Vaspin levels; obesity|type 2 diabetes mellitus rs1076019; Treatment outcomes for selective serotonin reuptake inhibitors (SSRIs) - response at last visit; major depressive disorder rs7404629; Osteoarthritis; osteoarthritis rs1049970; Rate of forced expiratory volume in 1 second (FEV1) decline (young adult women); lung disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 13) (view all) | 212 SGRIITITKSLDREK dbPAF
223 DREKQARYEIVVEAR dbPAF 392 QKKPLIGTVLAMDPD dbPAF 658 GEMDTTSYDVSVLNS dbPAF 665 YDVSVLNSVRRGGAK dbPAF 683 PALDARPSLYAQVQK dbPAF |
| Glycation (count: 2) | 197 MYQILKGKEYFAIDN PLMD
213 GRIITITKSLDREKQ PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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