| Tag | Content |
|---|---|
| UniProt Accession | IL3RB_HUMAN; P32927; |
| Entrez ID | 1439 |
| GenBank Protein ID | NM_000395.2; XM_005261340.3; |
| GenBank Nucleotide ID | NP_000386.1; XP_005261397.1; |
| Protein Name | Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131) |
| Gene Name | CSF2RB; IL3RB; IL5RB |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. |
| Sequence (Fasta) | MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT QDAQRLVNVT 60 LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC QSFVVTDVDY FSFQPDRPLG 120 TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD 180 SWEDAAILLS NTSQATLGPE HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG 240 DEAQPQNLEC FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL 300 HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD GDSYSLRWET 360 MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP ALEPSTRYWA RVRVRTSRTG 420 YNGIWSEWSE ARSWDTESVL PMWVLALIVI FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN 480 PSKSHLFQNG SAELWPPGSM SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE 540 DPKHVCDPPS GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR 600 SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ AVEVERRPSQ 660 GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG DTEDPGVASG YVSSADLVFT 720 PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS GPPGAPGPVK SGFEGYVELP PIEGRSPRSP 780 RNNPVPPEAK SPVLNPGERP ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS 840 SPGPGPEIKN LDQAFQVKKP PGQAVPQVPV IQLFKALKQQ DYLSLPPWEV NKPGEVC 898 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | OMIM:614370 ; SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 5 |
| DisGeNet (Curated) (count: 11) (view all) | C0013404; Dyspnea
C0033975; Psychotic Disorders C0034050; Pulmonary Alveolar Proteinosis C0035229; Respiratory Insufficiency C0036341; Schizophrenia C0041696; Unipolar Depression |
| HGMD (count: 1) | CM970401; Pulmonary alveolar proteinosis; Missense/nonsense
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| GWASdb (count: 13) (view all) | rs4821558; Crohn's disease; Crohn's disease
rs2075726; Ankylosing spondylitis; ankylosing spondylitis rs4821564; Aortic root size; cardiovascular system disease rs4821566; Smoking cessation; nicotine dependence rs9607391; Multiple complex diseases; Null rs9607397; Smoking cessation; nicotine dependence |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 14) (view all) | 390 WKDSKTETLQNAHSM dbPAF
396 ETLQNAHSMALPALE dbPAF 466 ALRFCGIYGYRLRRK dbPAF 468 RFCGIYGYRLRRKWE dbPAF 482 EEKIPNPSKSHLFQN dbPAF 491 SHLFQNGSAELWPPG dbPAF |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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