| Tag | Content |
|---|---|
| UniProt Accession | ELF1_HUMAN; P32519; |
| Entrez ID | 1997 |
| GenBank Protein ID | NM_001145353.1; NM_172373.3; XM_005266276.1; XM_005266277.3; XM_011534950.1; XM_017020409.1; XM_017020410.1; XM_017020411.1; XM_017020412.1; XM_017020413.1; |
| GenBank Nucleotide ID | NP_001138825.1; NP_758961.1; XP_005266333.1; XP_005266334.1; XP_011533252.1; XP_016875898.1; XP_016875899.1; XP_016875900.1; XP_016875901.1; XP_016875902.1; |
| Protein Name | ETS-related transcription factor Elf-1 (E74-like factor 1) |
| Gene Name | ELF1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. |
| Sequence (Fasta) | MAAVVQQNDL VFEFASNVME DERQLGDPAI FPAVIVEHVP GADILNSYAG LACVEEPNDM 60 ITESSLDVAE EEIIDDDDDD ITLTVEASCH DGDETIETIE AAEALLNMDS PGPMLDEKRI 120 NNNIFSSPED DMVVAPVTHV SVTLDGIPEV METQQVQEKY ADSPGASSPE QPKRKKGRKT 180 KPPRPDSPAT TPNISVKKKN KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL 240 VDSKAVSRLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYIN 300 DEDPSSSIES SDPSLSSSAT SNRNQTSRSR VSSSPGVKGG ATTVLKPGNS KAAKPKDPVE 360 VAQPSEVLRT VQPTQSPYPT QLFRTVHVVQ PVQAVPEGEA ARTSTMQDET LNSSVQSIRT 420 IQAPTQVPVV VSPRNQQLHT VTLQTVPLTT VIASTDPSAG TGSQKFILQA IPSSQPMTVL 480 KENVMLQSQK AGSPPSIVLG PAQVQQVLTS NVQTICNGTV SVASSPSFSA TAPVVTFSPR 540 SSQLVAHPPG TVITSVIKTQ ETKTLTQEVE KKESEDHLKE NTEKTEQQPQ PYVMVVSSSN 600 GFTSQVAMKQ NELLEPNSF |
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| Database | Annotation |
|---|---|
| GWASdb (count: 32) (view all) | rs77419017; Crohn's disease; Crohn's disease
rs75719223; Crohn's disease; Crohn's disease rs3736953; Obesity (extreme); obesity rs60129138; Crohn's disease; Crohn's disease rs9532689; Obesity (extreme); obesity rs7799; Obesity (extreme); obesity |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 30) (view all) | 110 EALLNMDSPGPMLDE dbPAF
126 RINNNIFSSPEDDMV dbPAF 127 INNNIFSSPEDDMVV dbPAF 160 TQQVQEKYADSPGAS dbPAF 163 VQEKYADSPGASSPE dbPAF 167 YADSPGASSPEQPKR dbPAF |
| Acetylation (count: 4) | 346 GGATTVLKPGNSKAA PLMD
351 VLKPGNSKAAKPKDP PLMD 354 PGNSKAAKPKDPVEV PLMD 558 TVITSVIKTQETKTL PLMD |
| Ubiquitination (count: 9) (view all) | 229 ATCPKYIKWTQREKG PLMD
239 QREKGIFKLVDSKAV PLMD 244 IFKLVDSKAVSRLWG PLMD 256 LWGKHKNKPDMNYET PLMD 279 YQRGILAKVEGQRLV PLMD 290 QRLVYQFKEMPKDLI PLMD |
| Sumoylation (count: 3) | 221 LLALLQDKATCPKYI PLMD
226 QDKATCPKYIKWTQR PLMD 279 YQRGILAKVEGQRLV PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |