P32119

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PRDX2_HUMAN; P32119;
Entrez ID 7001
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Peroxiredoxin-2 (EC 1.11.1.15) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1)
Gene Name PRDX2; NKEFB; TDPX1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionThiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
Sequence
(Fasta)		MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN 60
RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT 120
DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS 180
DTIKPNVDDS KEYFSKHN 199

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationParkinson's diseaseUT8917610816
[Reference]: Prx2 is phosphorylated at T89 in neurons treated with MPP+ and/or MPTP in animals in a calpain/Cdk5/p35-dependent manner. This phosphorylation reduces Prx2 peroxidase activity.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 13)
(view all)		MESH:D001195 ; Asbestosis
MESH:D002277 ; Carcinoma
MESH:D006528 ; Carcinoma, Hepatocellular
MESH:D004314 ; Down Syndrome
MESH:D004938 ; Esophageal Neoplasms
MESH:D007627 ; Keloid

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)		 108       IPLLADVTRRLSEDY     dbPAF
112       ADVTRRLSEDYGVLK     dbPAF
120       EDYGVLKTDEGIAYR     dbPAF
126       KTDEGIAYRGLFIID     dbPAF
142       KGVLRQITVNDLPVG     dbPAF
151       NDLPVGRSVDEALRL     dbPAF
Acetylation
(count: 11)
(view all)		 10        SGNARIGKPAPDFKA     PLMD
119       SEDYGVLKTDEGIAY     PLMD
135       GLFIIDGKGVLRQIT     PLMD
16        GKPAPDFKATAVVDG     PLMD
177       EVCPAGWKPGSDTIK     PLMD
184       KPGSDTIKPNVDDSK     PLMD
Ubiquitination
(count: 10)
(view all)		 10        SGNARIGKPAPDFKA     PLMD
119       SEDYGVLKTDEGIAY     PLMD
135       GLFIIDGKGVLRQIT     PLMD
16        GKPAPDFKATAVVDG     PLMD
177       EVCPAGWKPGSDTIK     PLMD
184       KPGSDTIKPNVDDSK     PLMD
Glycation
(count: 5)		 119       SEDYGVLKTDEGIAY     PLMD
135       GLFIIDGKGVLRQIT     PLMD
16        GKPAPDFKATAVVDG     PLMD
26        AVVDGAFKEVKLSDY     PLMD
29        DGAFKEVKLSDYKGK     PLMD
Malonylation
(count: 2)		 10        SGNARIGKPAPDFKA     PLMD
191       KPNVDDSKEYFSKHN     PLMD
Succinylation
(count: 6)		 10        SGNARIGKPAPDFKA     PLMD
119       SEDYGVLKTDEGIAY     PLMD
135       GLFIIDGKGVLRQIT     PLMD
191       KPNVDDSKEYFSKHN     PLMD
196       DSKEYFSKHN*****     PLMD
26        AVVDGAFKEVKLSDY     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource