P31994

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession FCG2B_HUMAN; P31994;
Entrez ID 2213
GenBank Protein ID NM_001002273.2; NM_001002274.2; NM_001002275.2; NM_001190828.1; NM_004001.4; XM_017000671.1; XM_017000672.1;
GenBank Nucleotide ID NP_001002273.1; NP_001002274.1; NP_001002275.1; NP_001177757.1; NP_003992.3; XP_016856160.1; XP_016856161.1;
Protein Name Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b) (CDw32) (Fc-gamma RII-b) (Fc-gamma-RIIb) (FcRII-b) (CD antigen CD32)
Gene Name FCGR2B; CD32; FCG2; IGFR2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionReceptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Sequence
(Fasta)		MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 60
VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 120
SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 180
FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA 240
VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA 300
LEEPDDQNRI 311

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationAlzheimer's diseasePY29227834631
[Reference]: Fc?RIIb-SHIP2 axis links A? to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model.

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
ALL
CTD (Curated)
(count: 4)		MESH:D001327 ; Autoimmune Diseases
MESH:D008180 ; Lupus Erythematosus, Systemic
MESH:D008288 ; Malaria
MESH:D009503 ; Neutropenia
DisGeNet (Curated)
(count: 4)		C0004364; Autoimmune Diseases
C0024141; Lupus Erythematosus, Systemic
C0024530; Malaria
C0027947; Neutropenia

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 2)		 292       GAENTITYSLLMHPD     dbPAF
293       AENTITYSLLMHPDA     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource