| Tag | Content |
|---|---|
| UniProt Accession | 1433S_HUMAN; P31947; |
| Entrez ID | 2810 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | 14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin) |
| Gene Name | SFN; HME1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.;p53-regulated inhibitor of G2/M progression. |
| Sequence (Fasta) | MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR 60 VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY 120 LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH 180 YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG 240 EAPQEPQS 249 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 8) (view all) | MESH:C538231
; Adenocarcinoma of lung MESH:D006528 ; Carcinoma, Hepatocellular MESH:D002294 ; Carcinoma, Squamous Cell MESH:D004938 ; Esophageal Neoplasms MESH:C562729 ; Esophageal Squamous Cell Carcinoma MESH:D007627 ; Keloid |
| DisGeNet (Curated) (count: 8) (view all) | C0007137; Squamous cell carcinoma
C0014859; Esophageal Neoplasms C0022548; Keloid C0024232; Lymphatic Metastasis C0026640; Mouth Neoplasms C0152013; Adenocarcinoma of lung (disorder) |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 22) (view all) | 116 KEAGDAESRVFYLKM dbPAF
120 DAESRVFYLKMKGDY dbPAF 127 YLKMKGDYYRYLAEV dbPAF 128 LKMKGDYYRYLAEVA dbPAF 130 MKGDYYRYLAEVATG dbPAF 136 RYLAEVATGDDKKRI dbPAF |
| Acetylation (count: 6) | 124 RVFYLKMKGDYYRYL PLMD
140 EVATGDDKKRIIDSA PLMD 159 QEAMDISKKEMPPTN PLMD 32 FMKGAVEKGEELSCE PLMD 49 NLLSVAYKNVVGGQR PLMD 68 VLSSIEQKSNEEGSE PLMD |
| Ubiquitination (count: 8) (view all) | 11 ASLIQKAKLAEQAER PLMD
122 ESRVFYLKMKGDYYR PLMD 124 RVFYLKMKGDYYRYL PLMD 159 QEAMDISKKEMPPTN PLMD 160 EAMDISKKEMPPTNP PLMD 49 NLLSVAYKNVVGGQR PLMD |
| Glycation (count: 1) | 124 RVFYLKMKGDYYRYL PLMD |