| Tag | Content |
|---|---|
| UniProt Accession | HNRH1_HUMAN; P31943; |
| Entrez ID | 3187 |
| GenBank Protein ID | NM_001257293.1; NM_005520.2; XM_017009415.1; XM_017009416.1; XM_017009417.1; |
| GenBank Nucleotide ID | NP_001244222.1; NP_005511.1; XP_016864904.1; XP_016864905.1; XP_016864906.1; |
| Protein Name | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] |
| Gene Name | HNRNPH1; HNRPH; HNRPH1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). |
| Sequence (Fasta) | MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE GRPSGEAFVE 60 LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT GPNSPDTAND GFVRLRGLPF 120 GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY 180 IEIFKSSRAE VRTHYDPPRK LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY 240 GGYDDYNGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA 300 TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA NMQHRYVELF 360 LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY 420 GGGYGGQSSM SGYDQVLQEN SSDFQSNIA |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D011471 ; Prostatic Neoplasms |
| DisGeNet (Curated) (count: 1) | C0033578; Prostatic Neoplasms |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 42) (view all) | 100 MDWVLKHTGPNSPDT dbPAF
104 LKHTGPNSPDTANDG dbPAF 107 TGPNSPDTANDGFVR dbPAF 151 PVDFQGRSTGEAFVQ dbPAF 161 EAFVQFASQEIAEKA dbPAF 180 KERIGHRYIEIFKSS dbPAF |
| Acetylation (count: 4) | 167 ASQEIAEKALKKHKE PLMD
185 HRYIEIFKSSRAEVR PLMD 35 QRFFSDCKIQNGAQG PLMD 98 VEMDWVLKHTGPNSP PLMD |
| Ubiquitination (count: 11) (view all) | 14 GGEGFVVKVRGLPWS PLMD
167 ASQEIAEKALKKHKE PLMD 171 IAEKALKKHKERIGH PLMD 185 HRYIEIFKSSRAEVR PLMD 200 THYDPPRKLMAMQRP PLMD 349 VAAMSKDKANMQHRY PLMD |
| Sumoylation (count: 4) | 14 GGEGFVVKVRGLPWS PLMD
185 HRYIEIFKSSRAEVR PLMD 349 VAAMSKDKANMQHRY PLMD 35 QRFFSDCKIQNGAQG PLMD |
| Methylation (count: 1) | 98 VEMDWVLKHTGPNSP PLMD |
| Succinylation (count: 2) | 185 HRYIEIFKSSRAEVR PLMD
35 QRFFSDCKIQNGAQG PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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