P31785

※ Protein Information

Tag	Content
UniProt Accession	IL2RG_HUMAN; P31785;
Entrez ID	3561
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Gene Name	IL2RG
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Common subunit for the receptors for a variety of interleukins. Functional Description Common subunit for the receptors for a variety of interleukins.
Sequence (Fasta)	MLKPSLPFTS LLFLQLPLLG VGLNTTILTP NGNEDTTADF FLTTMPTDSL SVSTLPLPEV 60 QCFVFNVEYM NCTWNSSSEP QPTNLTLHYW YKNSDNDKVQ KCSHYLFSEE ITSGCQLQKK 120 EIHLYQTFVV QLQDPREPRR QATQMLKLQN LVIPWAPENL TLHKLSESQL ELNWNNRFLN 180 HCLEHLVQYR TDWDHSWTEQ SVDYRHKFSL PSVDGQKRYT FRVRSRFNPL CGSAQHWSEW 240 SHPIHWGSNT SKENPFLFAL EAVVISVGSM GLIISLLCVY FWLERTMPRI PTLKNLEDLV 300 TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP 360 PCYTLKPET Fasta Sequence >P31785\|IL2RG\|Homo sapiens (Human) MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Glycosylation	Immunodeficiency		C	N125	15924140
1	[Reference]: We identified three children with mendelian susceptibility to mycobacterial disease who were homozygous with respect to a missense mutation in IFNGR2 creating a new N-glycosylation site in the IFNR2 chain.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D012751 ; Sezary Syndrome MESH:D053632 ; X-Linked Combined Immunodeficiency Diseases
DisGeNet (Curated) (count: 46) (view all)	C0001768; Agammaglobulinemia C0002170; Alopecia C0011606; Exfoliative dermatitis C0013604; Edema C0014457; Eosinophilia C0015230; Exanthema C0015967; Fever C0019209; Hepatomegaly C0023893; Liver Cirrhosis, Experimental C0029882; Otitis Media C0030469; Paranasal Sinus Diseases C0032285; Pneumonia C0033774; Pruritus C0036341; Schizophrenia C0036920; Sezary Syndrome C0037199; Sinusitis C0038002; Splenomegaly C0085110; Severe Combined Immunodeficiency C0151908; Dry skin C0162539; IgG Deficiency C0221765; Chronic schizophrenia C0231246; Failure to gain weight C0259817; Xerosis C0334008; Pachyderma C0401151; Chronic diarrhea C0427546; Atypical lymphocyte observed C0494261; Combined immunodeficiency C0497156; Lymphadenopathy C0685891; Congenital hypoplasia of thymus C0741796; Recurrent bronchitis C1279481; X-Linked Combined Immunodeficiency Diseases C1839304; Decreased number of CD4+ T cells C1839305; Decreased number of CD8+ T cells C1842714; Desquamation of skin soon after birth C1844384; Recurrent fungal infections C1845604; Recurrent bacterial meningitis C1845977; X- linked recessive C1848765; Sparse/absent eyebrows C2266639; Absence of eyebrows C2315100; Pediatric failure to thrive C2700553; Omenn Syndrome C3551430; Sparse or absent eyebrows C4020878; Diffusely thickened skin C4021956; Aplasia/Hypoplasia of the eyebrow C4024599; Chronic oral candidiasis C4228227; Small thymus
HGMD (count: 172) (view all)	CP962997; Immunodeficiency, severe combined; Complex rearrangements CD972273; Immunodeficiency, severe combined; Small deletions CD941711; Immunodeficiency, severe combined; Small deletions CD972272; Immunodeficiency, severe combined; Small deletions CD972271; Immunodeficiency, severe combined; Small deletions CD011627; Immunodeficiency, severe combined; Small deletions CD991765; Immunodeficiency, severe combined; Small deletions CD011620; Immunodeficiency, severe combined; Small deletions CD982710; Immunodeficiency, severe combined; Small deletions CD011621; Immunodeficiency, severe combined; Small deletions CD972269; Immunodeficiency, severe combined; Small deletions CD972268; Immunodeficiency, severe combined; Small deletions CD962046; Immunodeficiency, severe combined; Small deletions CD991766; Immunodeficiency, severe combined; Small deletions CD011619; Immunodeficiency, severe combined; Small deletions CD962048; Immunodeficiency, severe combined; Small deletions CD011617; Immunodeficiency, severe combined; Small deletions CD962047; Immunodeficiency, severe combined; Small deletions CD982711; Immunodeficiency, severe combined; Small deletions CD011622; Immunodeficiency, severe combined; Small deletions CD972276; Immunodeficiency, severe combined; Small deletions CD972270; Immunodeficiency, severe combined; Small deletions CD941712; Immunodeficiency, severe combined; Small deletions CD951748; Immunodeficiency, severe combined; Small deletions CD972277; Immunodeficiency, severe combined; Small deletions CD962049; Immunodeficiency, severe combined; Small deletions CD011626; Immunodeficiency, severe combined; Small deletions CD011625; Immunodeficiency, severe combined; Small deletions CD011624; Immunodeficiency, severe combined; Small deletions CD011618; Immunodeficiency, severe combined; Small deletions CD972274; Immunodeficiency, severe combined; Small deletions CD972275; Immunodeficiency, severe combined; Small deletions CD951747; Immunodeficiency, severe combined; Small deletions CD951749; Immunodeficiency, severe combined; Small deletions CG984379; Immunodeficiency, severe combined; Gross deletions CG962901; Immunodeficiency, severe combined; Gross deletions CG005044; Immunodeficiency, severe combined; Gross deletions CG952320; Immunodeficiency, severe combined; Gross deletions CX962708; Immunodeficiency, severe combined; Small indels CX972745; Immunodeficiency, severe combined; Small indels CX011715; Immunodeficiency, severe combined; Small indels CX972744; Immunodeficiency, severe combined; Small indels CX003991; Immunodeficiency, severe combined; Small indels CI002923; Immunodeficiency, severe combined; Small insertions CI992028; Immunodeficiency, severe combined; Small insertions CI951943; Immunodeficiency, severe combined; Small insertions CI972629; Immunodeficiency, severe combined; Small insertions CI972630; Immunodeficiency, severe combined; Small insertions CI972631; Immunodeficiency, severe combined; Small insertions CI002921; Immunodeficiency, severe combined; Small insertions CI951944; Immunodeficiency, severe combined; Small insertions CI002922; Immunodeficiency, severe combined; Small insertions CI011685; Immunodeficiency, severe combined; Small insertions CM970763; Immunodeficiency, severe combined; Missense/nonsense CM990751; Immunodeficiency, severe combined; Missense/nonsense CM962691; Immunodeficiency, severe combined; Missense/nonsense CM930430; Immunodeficiency, severe combined; Missense/nonsense CM962676; Immunodeficiency, severe combined; Missense/nonsense CM076239; Immunodeficiency, severe combined; Missense/nonsense CM940975; Immunodeficiency, severe combined; Missense/nonsense CM960879; Immunodeficiency, severe combined; Missense/nonsense CM011373; Immunodeficiency, severe combined; Missense/nonsense CM981064; Immunodeficiency, severe combined; Missense/nonsense CM940976; Immunodeficiency, severe combined; Missense/nonsense CM960880; Immunodeficiency, severe combined; Missense/nonsense CM930431; Immunodeficiency, severe combined; Missense/nonsense CM011374; Immunodeficiency, severe combined; Missense/nonsense CM002790; Immunodeficiency, severe combined; Missense/nonsense CM011375; Immunodeficiency, severe combined; Missense/nonsense CM011376; Immunodeficiency, severe combined; Missense/nonsense CM002791; Immunodeficiency, severe combined; Missense/nonsense CM981065; Immunodeficiency, severe combined; Missense/nonsense CM960881; Immunodeficiency, severe combined; Missense/nonsense CM962677; Immunodeficiency, severe combined; Missense/nonsense CM002792; Immunodeficiency, severe combined; Missense/nonsense CM011377; Immunodeficiency, severe combined; Missense/nonsense CM930432; Immunodeficiency, severe combined; Missense/nonsense CM011378; Immunodeficiency, severe combined; Missense/nonsense CM970764; Immunodeficiency, severe combined; Missense/nonsense CM011379; Immunodeficiency, severe combined; Missense/nonsense CM930433; Immunodeficiency, severe combined; Missense/nonsense CM970765; Immunodeficiency, severe combined; Missense/nonsense CM970766; Immunodeficiency, severe combined; Missense/nonsense CM002793; Immunodeficiency, severe combined; Missense/nonsense CM011380; Immunodeficiency, severe combined; Missense/nonsense CM970767; Immunodeficiency, severe combined; Missense/nonsense CM981066; Immunodeficiency, severe combined; Missense/nonsense CM960882; Immunodeficiency, severe combined; Missense/nonsense CM057332; Immunodeficiency, severe combined; Missense/nonsense CM970768; Immunodeficiency, severe combined; Missense/nonsense CM940977; Immunodeficiency, severe combined; Missense/nonsense CM970769; Immunodeficiency, severe combined; Missense/nonsense CM011381; Immunodeficiency, severe combined; Missense/nonsense CM085473; Immunodeficiency, severe combined; Missense/nonsense CM002794; Immunodeficiency, severe combined; Missense/nonsense CM930434; Immunodeficiency, severe combined; Missense/nonsense CM940978; Immunodeficiency, severe combined; Missense/nonsense CM011382; Immunodeficiency, severe combined; Missense/nonsense CM970770; Immunodeficiency, severe combined; Missense/nonsense CM981067; Immunodeficiency, severe combined; Missense/nonsense CM970771; Immunodeficiency, severe combined; Missense/nonsense CM970772; Immunodeficiency, severe combined; Missense/nonsense CM011384; Immunodeficiency, severe combined; Missense/nonsense CM011383; Immunodeficiency, severe combined; Missense/nonsense CM011385; Immunodeficiency, severe combined; Missense/nonsense CM085474; Immunodeficiency, severe combined; Missense/nonsense CM950691; Immunodeficiency, severe combined; Missense/nonsense CM011386; Immunodeficiency, severe combined; Missense/nonsense CM002795; Immunodeficiency, severe combined; Missense/nonsense CM970773; Immunodeficiency, severe combined; Missense/nonsense CM970774; Immunodeficiency, severe combined; Missense/nonsense CM970775; Immunodeficiency, severe combined; Missense/nonsense CM056342; Immunodeficiency, severe combined; Missense/nonsense CM011387; Immunodeficiency, severe combined; Missense/nonsense CM064057; Immunodeficiency, severe combined; Missense/nonsense CM970776; Immunodeficiency, severe combined; Missense/nonsense CM950692; Immunodeficiency, severe combined; Missense/nonsense CM970777; Immunodeficiency, severe combined; Missense/nonsense CM950694; Immunodeficiency, severe combined; Missense/nonsense CM950693; Immunodeficiency, severe combined; Missense/nonsense CM970778; Immunodeficiency, severe combined; Missense/nonsense CM970779; Immunodeficiency, severe combined; Missense/nonsense CM011388; Immunodeficiency, severe combined; Missense/nonsense CM011389; Immunodeficiency, severe combined; Missense/nonsense CM970780; Immunodeficiency, severe combined; Missense/nonsense CM950695; Immunodeficiency, severe combined; Missense/nonsense CM011390; Immunodeficiency, severe combined; Missense/nonsense CM942063; Immunodeficiency, severe combined; Missense/nonsense CM942094; Immunodeficiency, severe combined; Missense/nonsense CM940979; Immunodeficiency, severe combined; Missense/nonsense CM011391; Immunodeficiency, severe combined; Missense/nonsense CM003937; Immunodeficiency, severe combined; Missense/nonsense CM061799; Immunodeficiency, severe combined; Missense/nonsense CM970781; Immunodeficiency, severe combined; Missense/nonsense CM011392; Immunodeficiency, severe combined; Missense/nonsense CM960883; Immunodeficiency, severe combined; Missense/nonsense CM950696; Immunodeficiency, severe combined; Missense/nonsense CM930435; Immunodeficiency, severe combined; Missense/nonsense CM950697; Immunodeficiency, severe combined; Missense/nonsense CM950698; Immunodeficiency, severe combined; Missense/nonsense CM930436; Immunodeficiency, severe combined; Missense/nonsense CM970782; Immunodeficiency, severe combined; Missense/nonsense CM011393; Immunodeficiency, severe combined; Missense/nonsense CS942078; Immunodeficiency, severe combined; Splicing CS971765; Immunodeficiency, severe combined; Splicing CS083945; Immunodeficiency, severe combined; Splicing CS982231; Immunodeficiency, severe combined; Splicing CS971766; Immunodeficiency, severe combined; Splicing CS951451; Immunodeficiency, severe combined; Splicing CS971767; Immunodeficiency, severe combined; Splicing CS002888; Immunodeficiency, severe combined; Splicing CS971768; Immunodeficiency, severe combined; Splicing CS971769; Immunodeficiency, severe combined; Splicing CS041121; Immunodeficiency, severe combined; Splicing CS930839; Immunodeficiency, severe combined; Splicing CS011538; Immunodeficiency, severe combined; Splicing CS951452; Immunodeficiency, severe combined; Splicing CS971770; Immunodeficiency, severe combined; Splicing CS982232; Immunodeficiency, severe combined; Splicing CS011539; Immunodeficiency, severe combined; Splicing CS011540; Immunodeficiency, severe combined; Splicing CS002889; Immunodeficiency, severe combined; Splicing CS971771; Immunodeficiency, severe combined; Splicing CS971772; Immunodeficiency, severe combined; Splicing CS011541; Immunodeficiency, severe combined; Splicing CS011542; Immunodeficiency, severe combined; Splicing CS993990; Immunodeficiency, severe combined; Splicing CS971773; Immunodeficiency, severe combined; Splicing CS003976; Immunodeficiency, severe combined; Splicing CS971774; Immunodeficiency, severe combined; Splicing CS971775; Immunodeficiency, severe combined; Splicing CS011543; Immunodeficiency, severe combined; Splicing

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 10) (view all)	204 WTEQSVDYRHKFSLP dbPAF 292 RTMPRIPTLKNLEDL dbPAF 301 KNLEDLVTEYHGNFS dbPAF 303 LEDLVTEYHGNFSAW dbPAF 308 TEYHGNFSAWSGVSK dbPAF 320 VSKGLAESLQPDYSE dbPAF 325 AESLQPDYSERLCLV dbPAF 326 ESLQPDYSERLCLVS dbPAF 357 PCNQHSPYWAPPCYT dbPAF 363 PYWAPPCYTLKPET* dbPAF
Ubiquitination (count: 9) (view all)	101 SDNDKVQKCSHYLFS PLMD 119 TSGCQLQKKEIHLYQ PLMD 120 SGCQLQKKEIHLYQT PLMD 147 RQATQMLKLQNLVIP PLMD 207 QSVDYRHKFSLPSVD PLMD 217 LPSVDGQKRYTFRVR PLMD 294 MPRIPTLKNLEDLVT PLMD 315 SAWSGVSKGLAESLQ PLMD 98 YKNSDNDKVQKCSHY PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

F5H146	P31785	BioGRID
O00308	P31785	HPRD
P04632	P31785	HPRD
P05112	P31785	HPRD; IntAct
P05362	P31785	HPRD
P13232	P31785	HPRD; DIP; IntAct
P14784	P31785	HPRD; DIP
P16871	P31785	HPRD
P23458	P31785	HPRD
P24394	P31785	HPRD; IntAct
P29353	P31785	HPRD
P30530	P31785	HPRD
P31785	P40933	HPRD; DIP
P31785	P42224	HPRD
P31785	P42229	HPRD
P31785	P50748	BioGRID
P31785	P52333	HPRD; DIP
P31785	P60568	HPRD; DIP
P31785	P62993	IntAct
P31785	Q01113	HPRD
P31785	Q12913	HPRD
P31785	Q13043	IntAct
P31785	Q13261	HPRD
P31785	Q15464	HPRD
P31785	Q6ZU65	BioGRID
P31785	Q9H0M0	HPRD

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction