Tag | Content |
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UniProt Accession | AKT2_HUMAN; P31751; |
Entrez ID | 208 |
GenBank Protein ID | NM_001330511.1; NM_001626.5; XM_011526614.1; XM_011526615.1; XM_011526616.1; XM_011526618.1; XM_011526619.1; XM_011526620.1; XM_017026470.1; |
GenBank Nucleotide ID | NP_001317440.1; NP_001617.1; XP_011524916.1; XP_011524917.1; XP_011524918.1; XP_011524920.1; XP_011524921.1; XP_011524922.1; XP_016881959.1; |
Protein Name | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta) |
Gene Name | AKT2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the (view all) |
Sequence (Fasta) | MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 60 QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM 120 DYKCGSPSDS STTEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 180 KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 240 LSRERVFTEE RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 300 ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 360 LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 420 KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG LLELDQRTHF PQFSYSASIR 480 E 482 |
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Database | Annotation |
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Cancer Gene Census | ovarian, pancreatic |
CTD (Curated) (count: 5) | MESH:D001943
; Breast Neoplasms MESH:D003924 ; Diabetes Mellitus, Type 2 OMIM:240900 ; HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY MESH:D052496 ; Lipodystrophy, Familial Partial MESH:C538339 ; Nasopharyngeal carcinoma |
DisGeNet (Curated) (count: 28) (view all) | C0000889; Acanthosis Nigricans
C0005586; Bipolar Disorder C0011860; Diabetes Mellitus, Non-Insulin-Dependent C0014544; Epilepsy C0018418; Gynecomastia C0019209; Hepatomegaly |
HGMD (count: 1) | CM041234; Severe insulin resistance and diabetes mellitus; Missense/nonsense
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GWASdb (count: 3) | rs969531; Fibrinogen; cardiovascular system disease
rs969531; Progressive supranuclear palsy; progressive supranuclear palsy rs7250897; Fibrinogen; cardiovascular system disease |
PTM | Modification Sites |
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Phosphorylation (count: 29) (view all) | 122 PGEDPMDYKCGSPSD dbPAF
126 PMDYKCGSPSDSSTT dbPAF 128 DYKCGSPSDSSTTEE dbPAF 130 KCGSPSDSSTTEEME dbPAF 131 CGSPSDSSTTEEMEV dbPAF 133 SPSDSSTTEEMEVAV dbPAF |
Acetylation (count: 1) | 386 SLLAGLLKKDPKQRL PLMD |
Ubiquitination (count: 12) (view all) | 111 QMVANSLKQRAPGED PLMD
14 IKEGWLHKRGEYIKT PLMD 142 EMEVAVSKARAKVTM PLMD 146 AVSKARAKVTMNDFD PLMD 156 MNDFDYLKLLGKGTF PLMD 160 DYLKLLGKGTFGKVI PLMD |
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