Tag | Content |
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UniProt Accession | AKT1_MOUSE; P31750; |
Entrez ID | 11651 |
GenBank Protein ID | NM_001165894.1; NM_001331107.1; NM_009652.3; XM_006515415.1; |
GenBank Nucleotide ID | NP_001159366.1; NP_001318036.1; NP_033782.1; XP_006515478.1; |
Protein Name | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene) |
Gene Name | Akt1; Akt; Rac |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the (view all) |
Sequence (Fasta) | MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQRES PLNNFSVAQC 60 QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWA TAIQTVADGL KRQEEETMDF 120 RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 180 LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 240 RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 300 KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 360 ILMEEIRFPR TLGPEAKSLL SGLLKKDPTQ RLGGGSEDAK EIMQHRFFAN IVWQDVYEKK 420 LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA 480 481 |
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Database | Annotation |
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CTD (Curated) (count: 30) (view all) | MESH:D011125
; Adenomatous Polyposis Coli MESH:D019969 ; Amphetamine-Related Disorders MESH:C562942 ; Aortic Valve, Calcification of MESH:D001943 ; Breast Neoplasms MESH:D002294 ; Carcinoma, Squamous Cell MESH:C535575 ; Carcinoma, squamous cell of head and neck |
PTM | Modification Sites |
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Phosphorylation (count: 18) (view all) | 117 LKRQEEETMDFRSGS dbPAF
122 EETMDFRSGSPSDNS dbPAF 124 TMDFRSGSPSDNSGA dbPAF 126 DFRSGSPSDNSGAEE dbPAF 129 SGSPSDNSGAEEMEV dbPAF 137 GAEEMEVSLAKPKHR dbPAF |
Acetylation (count: 2) | 179 TGRYYAMKILKKEVI PLMD
276 NVVYRDLKLENLMLD PLMD |
Ubiquitination (count: 2) | 276 NVVYRDLKLENLMLD PLMD
30 RPRYFLLKNDGTFIG PLMD |
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