P31750

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession AKT1_MOUSE; P31750;
Entrez ID 11651
GenBank Protein ID NM_001165894.1; NM_001331107.1; NM_009652.3; XM_006515415.1;
GenBank Nucleotide ID NP_001159366.1; NP_001318036.1; NP_033782.1; XP_006515478.1;
Protein Name RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene)
Gene Name Akt1; Akt; Rac
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionAKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the (view all)
Sequence
(Fasta)
MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQRES PLNNFSVAQC 60
QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWA TAIQTVADGL KRQEEETMDF 120
RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI 180
LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS 240
RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI 300
KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL 360
ILMEEIRFPR TLGPEAKSLL SGLLKKDPTQ RLGGGSEDAK EIMQHRFFAN IVWQDVYEKK 420
LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA 480
481

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationBrain cancer/tumorP15026334
[Reference]: Furthermore, forced expression of Cyr61 in the glioma cells activated phosphatidylinositol 4'-kinase pathway, resulting in prominent phosphorylation of Akt and the antiapoptotic protein Bad.
2Tyrosine PhosphorylationProstate cancer/carcinoma/adenocarcinomaUY17620333297
[Reference]: Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
3Serine PhosphorylationDiabetes mellitusDS47315033922; 16777975; 17130464
[Reference]: In the brain, as suggested by decreased IR beta-subunit (IRbeta) Y1162/1163 autophosphorylation and reduced phosphatidylinositol 3 (PI3)-kinase/pS473-AKT/Protein kinase (PK)-B in these same brain regions.?
4Serine PhosphorylationMelanomaDF-1 cells?US47326565903
[Reference]: In agreement with the IHC data, PTENNull?melanomas displayed higher levels of pS473-AKT?
5Serine PhosphorylationEndometrial cancer/carcinomaUS47316585156
[Reference]: To assess whether this functional link exists?in vivo, we did immunohistochemistry on serial uterine sections from wild-type and?Pten?heterozygous mice using antibodies recognizing the phosphorylated, active forms of both Akt (Ser473) and ER? (Ser167). The endometrial glands of wild-type mouse uteri express low levels of both active Akt- and Ser167-phosphorylated ER?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 30)
(view all)
MESH:D011125 ; Adenomatous Polyposis Coli
MESH:D019969 ; Amphetamine-Related Disorders
MESH:C562942 ; Aortic Valve, Calcification of
MESH:D001943 ; Breast Neoplasms
MESH:D002294 ; Carcinoma, Squamous Cell
MESH:C535575 ; Carcinoma, squamous cell of head and neck

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 18)
(view all)
117       LKRQEEETMDFRSGS     dbPAF
122       EETMDFRSGSPSDNS     dbPAF
124       TMDFRSGSPSDNSGA     dbPAF
126       DFRSGSPSDNSGAEE     dbPAF
129       SGSPSDNSGAEEMEV     dbPAF
137       GAEEMEVSLAKPKHR     dbPAF
Acetylation
(count: 2)
179       TGRYYAMKILKKEVI     PLMD
276       NVVYRDLKLENLMLD     PLMD
Ubiquitination
(count: 2)
276       NVVYRDLKLENLMLD     PLMD
30        RPRYFLLKNDGTFIG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource