P31645

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SC6A4_HUMAN; P31645;
Entrez ID 6532
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)
Gene Name SLC6A4; HTT; SERT
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionSerotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Sequence
(Fasta)		METTPLNSQK QLSACEDGED CQENGVLQKV VPTPGDKVES GQISNGYSAV PSPGAGDDTR 60
HSIPATTTTL VAELHQGERE TWGKKVDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLLP 120
YTIMAIFGGI PLFYMELALG QYHRNGCISI WRKICPIFKG IGYAICIIAF YIASYYNTIM 180
AWALYYLISS FTDQLPWTSC KNSWNTGNCT NYFSEDNITW TLHSTSPAEE FYTRHVLQIH 240
RSKGLQDLGG ISWQLALCIM LIFTVIYFSI WKGVKTSGKV VWVTATFPYI ILSVLLVRGA 300
TLPGAWRGVL FYLKPNWQKL LETGVWIDAA AQIFFSLGPG FGVLLAFASY NKFNNNCYQD 360
ALVTSVVNCM TSFVSGFVIF TVLGYMAEMR NEDVSEVAKD AGPSLLFITY AEAIANMPAS 420
TFFAIIFFLM LITLGLDSTF AGLEGVITAV LDEFPHVWAK RRERFVLAVV ITCFFGSLVT 480
LTFGGAYVVK LLEEYATGPA VLTVALIEAV AVSWFYGITQ FCRDVKEMLG FSPGWFWRIC 540
WVAISPLFLL FIICSFLMSP PQLRLFQYNY PYWSIILGYC IGTSSFICIP TYIAYRLIIT 600
PGTFKERIIK SITPETPTEI PCGDIRLNAV 631

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PalmitoylationHuntington's diseaseD24347167
[Reference]: We found that HTT overexpression resulted in a palmitoylation- and BDNF-dependent increase in PSD-95 clustering at synaptic sites in striatal spiny projection neurons (SPNs) co-cultured with cortical neurons. Surprisingly, the latter effect was mediated presynaptically, as HTT overexpression in cortical neurons alone was sufficient to increase PSD-95 clustering in the postsynaptic SPNs.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 19)
(view all)		MESH:D000437 ; Alcoholism
MESH:D019969 ; Amphetamine-Related Disorders
MESH:D001008 ; Anxiety Disorders
MESH:D020817 ; Asperger Syndrome
MESH:D001321 ; Autistic Disorder
MESH:D001714 ; Bipolar Disorder
HGMD
(count: 18)
(view all)		CE962666; Unipolar disorder, association with; Repeat variations
CG962946; Anxiety related traits, association with; Gross deletions
CM057893; Enhanced 5-HT transport activity, association with; Missense/nonsense
CM057408; Autism, association with; Missense/nonsense
CM057892; MAPK nonresponsiveness, association with; Missense/nonsense
CM057895; Enhanced 5-HT transport activity, association with; Missense/nonsense
GWASdb
(count: 5)		rs7212502; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs7212502; HDL cholesterol; cholesterol ester storage disease|cholesterol embolism|coronary artery disease
rs16965623; Multiple complex diseases; Null
rs25531; Drug response to Citalopram; Null
rs4795541; Drug response to Escitalopram; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)		 13        LNSQKQLSACEDGED     dbPAF
142       MELALGQYHRNGCIS     dbPAF
149       YHRNGCISIWRKICP     dbPAF
276       SIWKGVKTSGKVVWV     dbPAF
277       IWKGVKTSGKVVWVT     dbPAF
47        SGQISNGYSAVPSPG     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource