| Tag | Content |
|---|---|
| UniProt Accession | CLIP1_HUMAN; P30622; |
| Entrez ID | 6249 |
| GenBank Protein ID | NM_001247997.1; NM_002956.2; NM_198240.1; XM_017019786.1; XM_017019790.1; |
| GenBank Nucleotide ID | NP_001234926.1; NP_002947.1; NP_937883.1; XP_016875275.1; XP_016875279.1; |
| Protein Name | CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) |
| Gene Name | CLIP1; CYLN1; RSN |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. |
| Sequence (Fasta) | MSMLKPSGLK APTKILKPGS TALKTPTAVV APVEKTISSE KASSTPSSET QEEFVDDFRV 60 GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND GSVAGVRYFQ CEPLKGIFTR 120 PSKLTRKVQA EDEANGLQTT PASRATSPLC TSTASMVSSS PSTPSNIPQK PSQPAAKEPS 180 ATPPISNLTK TASESISNLS EAGSIKKGER ELKIGDRVLV GGTKAGVVRF LGETDFAKGE 240 WCGVELDEPL GKNDGAVAGT RYFQCQPKYG LFAPVHKVTK IGFPSTTPAK AKANAVRRVM 300 ATTSASLKRS PSASSLSSMS SVASSVSSRP SRTGLLTETS SRYARKISGT TALQEALKEK 360 QQHIEQLLAE RDLERAEVAK ATSHVGEIEQ ELALARDGHD QHVLELEAKM DQLRTMVEAA 420 DREKVELLNQ LEEEKRKVED LQFRVEEESI TKGDLEQKSQ ISEDPENTQT KLEHARIKEL 480 EQSLLFEKTK ADKLQRELED TRVATVSEKS RIMELEKDLA LRVQEVAELR RRLESNKPAG 540 DVDMSLSLLQ EISSLQEKLE VTRTDHQREI TSLKEHFGAR EETHQKEIKA LYTATEKLSK 600 ENESLKSKLE HANKENSDVI ALWKSKLETA IASHQQAMEE LKVSFSKGLG TETAEFAELK 660 TQIEKMRLDY QHEIENLQNQ QDSERAAHAK EMEALRAKLM KVIKEKENSL EAIRSKLDKA 720 EDQHLVEMED TLNKLQEAEI KVKELEVLQA KCNEQTKVID NFTSQLKATE EKLLDLDALR 780 KASSEGKSEM KKLRQQLEAA EKQIKHLEIE KNAESSKASS ITRELQGREL KLTNLQENLS 840 EVSQVKETLE KELQILKEKF AEASEEAVSV QRSMQETVNK LHQKEEQFNM LSSDLEKLRE 900 NLADMEAKFR EKDEREEQLI KAKEKLENDI AEIMKMSGDN SSQLTKMNDE LRLKERDVEE 960 LQLKLTKANE NASFLQKSIE DMTVKAEQSQ QEAAKKHEEE KKELERKLSD LEKKMETSHN 1020 QCQELKARYE RATSETKTKH EEILQNLQKT LLDTEDKLKG AREENSGLLQ ELEELRKQAD 1080 KAKAAQTAED AMQIMEQMTK EKTETLASLE DTKQTNAKLQ NELDTLKENN LKNVEELNKS 1140 KELLTVENQK MEEFRKEIET LKQAAAQKSQ QLSALQEENV KLAEELGRSR DEVTSHQKLE 1200 EERSVLNNQL LEMKKRESKF IKDADEEKAS LQKSISITSA LLTEKDAELE KLRNEVTVLR 1260 GENASAKSLH SVVQTLESDK VKLELKVKNL ELQLKENKRQ LSSSSGNTDT QADEDERAQE 1320 SQIDFLNSVI VDLQRKNQDL KMKVEMMSEA ALNGNGDDLN NYDSDDQEKQ SKKKPRLFCD 1380 ICDCFDLHDT EDCPTQAQMS EDPPHSTHHG SRGEERPYCE ICEMFGHWAT NCNDDETF 1439 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | Spitzoid tumour |
| GWASdb (count: 10) (view all) | rs12423987; Serum metabolites; Null
rs11057421; Tunica Media; heart disease rs7956480; Amyotrophic lateral sclerosis (sporadic); amyotrophic lateral sclerosis rs882969; Acute lung injury; lung disease rs10846664; Coronary Artery Disease; coronary artery disease rs3817012; Acute lung injury; lung disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 91) (view all) | 1009 KELERKLSDLEKKME dbPAF
1066 KGAREENSGLLQELE dbPAF 1087 DKAKAAQTAEDAMQI dbPAF 1140 NVEELNKSKELLTVE dbPAF 1145 NKSKELLTVENQKME dbPAF 1169 KQAAAQKSQQLSALQ dbPAF |
| Acetylation (count: 9) (view all) | 1026 HNQCQELKARYERAT PLMD
1039 ATSETKTKHEEILQN PLMD 14 SGLKAPTKILKPGST PLMD 17 KAPTKILKPGSTALK PLMD 24 KPGSTALKTPTAVVA PLMD 268 RYFQCQPKYGLFAPV PLMD |
| Ubiquitination (count: 7) (view all) | 1215 NQLLEMKKRESKFIK PLMD
127 RPSKLTRKVQAEDEA PLMD 435 LNQLEEEKRKVEDLQ PLMD 517 SRIMELEKDLALRVQ PLMD 690 SERAAHAKEMEALRA PLMD 787 RKASSEGKSEMKKLR PLMD |
| Malonylation (count: 4) | 123 GIFTRPSKLTRKVQA PLMD
224 RVLVGGTKAGVVRFL PLMD 360 LQEALKEKQQHIEQL PLMD 706 LMKVIKEKENSLEAI PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |