Tag | Content |
---|---|
UniProt Accession | UFO_HUMAN; P30530; |
Entrez ID | 558 |
GenBank Protein ID | NM_001699.5; NM_021913.4; |
GenBank Nucleotide ID | NP_001690.2; NP_068713.2; |
Protein Name | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) |
Gene Name | AXL; UFO |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candid(view all) |
Sequence (Fasta) | MAWRCPRMGR VPLAWCLALC GWACMAPRGT QAEESPFVGN PGNITGARGL TGTLRCQLQV 60 QGEPPEVHWL RDGQILELAD STQTQVPLGE DEQDDWIVVS QLRITSLQLS DTGQYQCLVF 120 LGHQTFVSQP GYVGLEGLPY FLEEPEDRTV AANTPFNLSC QAQGPPEPVD LLWLQDAVPL 180 ATAPGHGPQR SLHVPGLNKT SSFSCEAHNA KGVTTSRTAT ITVLPQQPRN LHLVSRQPTE 240 LEVAWTPGLS GIYPLTHCTL QAVLSNDGMG IQAGEPDPPE EPLTSQASVP PHQLRLGSLH 300 PHTPYHIRVA CTSSQGPSSW THWLPVETPE GVPLGPPENI SATRNGSQAF VHWQEPRAPL 360 QGTLLGYRLA YQGQDTPEVL MDIGLRQEVT LELQGDGSVS NLTVCVAAYT AAGDGPWSLP 420 VPLEAWRPGQ AQPVHQLVKE PSTPAFSWPW WYVLLGAVVA AACVLILALF LVHRRKKETR 480 YGEVFEPTVE RGELVVRYRV RKSYSRRTTE ATLNSLGISE ELKEKLRDVM VDRHKVALGK 540 TLGEGEFGAV MEGQLNQDDS ILKVAVKTMK IAICTRSELE DFLSEAVCMK EFDHPNVMRL 600 IGVCFQGSER ESFPAPVVIL PFMKHGDLHS FLLYSRLGDQ PVYLPTQMLV KFMADIASGM 660 EYLSTKRFIH RDLAARNCML NENMSVCVAD FGLSKKIYNG DYYRQGRIAK MPVKWIAIES 720 LADRVYTSKS DVWSFGVTMW EIATRGQTPY PGVENSEIYD YLRQGNRLKQ PADCLDGLYA 780 LMSRCWELNP QDRPSFTELR EDLENTLKAL PPAQEPDEIL YVNMDEGGGY PEPPGAAGGA 840 DPPTQPDPKD SCSCLTAAEV HPAGRYVLCP STTPSPAQPA DRGSPAAPGQ EDGA 895 |
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Database | Annotation |
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CTD (Curated) (count: 11) (view all) | MESH:D003928
; Diabetic Nephropathies MESH:C562785 ; Idiopathic Hypogonadotropic Hypogonadism MESH:D007680 ; Kidney Neoplasms MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D009361 ; Neoplasm Invasiveness MESH:D009362 ; Neoplasm Metastasis |
GWASdb (count: 1) | rs6508974; Urinary metabolites; kidney disease |
PTM | Modification Sites |
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Phosphorylation (count: 24) (view all) | 100 QDDWIVVSQLRITSL dbPAF
149 LEEPEDRTVAANTPF dbPAF 200 HVPGLNKTSSFSCEA dbPAF 201 VPGLNKTSSFSCEAH dbPAF 202 PGLNKTSSFSCEAHN dbPAF 204 LNKTSSFSCEAHNAK dbPAF |
Ubiquitination (count: 8) (view all) | 523 LGISEELKEKLRDVM PLMD
540 RHKVALGKTLGEGEF PLMD 563 NQDDSILKVAVKTMK PLMD 590 LSEAVCMKEFDHPNV PLMD 666 GMEYLSTKRFIHRDL PLMD 696 ADFGLSKKIYNGDYY PLMD |
Network | Interaction | ||
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A | B | Source | |