P30307

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession MPIP3_HUMAN; P30307;
Entrez ID 995
GenBank Protein ID NM_001287582.1; NM_001318098.1; NM_001790.4; NM_022809.3; XM_011543762.1;
GenBank Nucleotide ID NP_001274511.1; NP_001305027.1; NP_001781.2; NP_073720.1; XP_011542064.1;
Protein Name M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)
Gene Name CDC25C
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionFunctions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.
Sequence
(Fasta)
MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL 60
SILSGGTPKR CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK 120
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP 180
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK 240
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ 300
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK 360
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF 420
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP 474

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationLeukemiaP11202906
[Reference]: Herein, we show for the first time that endogenous human PLK protein immunoprecipitated from the G2/M-arrested Jurkat cells directly phosphorylates human cdc25C.


※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 35)
(view all)
122       DQHLMKCSPAQLLCS     dbPAF
129       SPAQLLCSTPNGLDR     dbPAF
130       PAQLLCSTPNGLDRG     dbPAF
14        SSTREEGSSGSGPSF     dbPAF
146       RKRDAMCSSSANKEN     dbPAF
148       RDAMCSSSANKENDN     dbPAF
Acetylation
(count: 2)
251       KYFSGQGKLRKGLCL     PLMD
52        VPRTPVGKFLGDSAN     PLMD
Ubiquitination
(count: 10)
(view all)
251       KYFSGQGKLRKGLCL     PLMD
260       RKGLCLKKTVSLCDI     PLMD
27        SFRSNQRKMLNLLLE     PLMD
288       HLIGDFSKVCALPTV     PLMD
298       ALPTVSGKHQDLKYV     PLMD
317       VAALLSGKFQGLIEK     PLMD