| Tag | Content |
|---|---|
| UniProt Accession | MPIP1_HUMAN; P30304; |
| Entrez ID | 993 |
| GenBank Protein ID | NM_001789.2; NM_201567.1; XM_011534316.1; |
| GenBank Nucleotide ID | NP_001780.2; NP_963861.1; XP_011532618.1; |
| Protein Name | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) |
| Gene Name | CDC25A |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. |
| Sequence (Fasta) | MELGPEPPHR RRLLFACSPP PASQPVVKAL FGASAAGGLS PVTNLTVTMD QLQGLGSDYE 60 QPLEVKNNSN LQRMGSSEST DSGFCLDSPG PLDSKENLEN PMRRIHSLPQ KLLGCSPALK 120 RSHSDSLDHD IFQLIDPDEN KENEAFEFKK PVRPVSRGCL HSHGLQEGKD LFTQRQNSAP 180 ARMLSSNERD SSEPGNFIPL FTPQSPVTAT LSDEDDGFVD LLDGENLKNE EETPSCMASL 240 WTAPLVMRTT NLDNRCKLFD SPSLCSSSTR SVLKRPERSQ EESPPGSTKR RKSMSGASPK 300 ESTNPEKAHE TLHQSLSLAS SPKGTIENIL DNDPRDLIGD FSKGYLFHTV AGKHQDLKYI 360 SPEIMASVLN GKFANLIKEF VIIDCRYPYE YEGGHIKGAV NLHMEEEVED FLLKKPIVPT 420 DGKRVIVVFH CEFSSERGPR MCRYVRERDR LGNEYPKLHY PELYVLKGGY KEFFMKCQSY 480 CEPPSYRPMH HEDFKEDLKK FRTKSRTWAG EKSKREMYSR LKKL 525 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 2) | rs3731544; Multiple complex diseases; Null
rs3731539; Alcohol dependence; alcohol dependence |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 29) (view all) | 107 NPMRRIHSLPQKLLG dbPAF
116 PQKLLGCSPALKRSH dbPAF 124 PALKRSHSDSLDHDI dbPAF 126 LKRSHSDSLDHDIFQ dbPAF 178 LFTQRQNSAPARMLS dbPAF 18 RRLLFACSPPPASQP dbPAF |
| Ubiquitination (count: 18) (view all) | 111 RIHSLPQKLLGCSPA PLMD
120 LGCSPALKRSHSDSL PLMD 169 SHGLQEGKDLFTQRQ PLMD 257 TNLDNRCKLFDSPSL PLMD 289 ESPPGSTKRRKSMSG PLMD 300 SMSGASPKESTNPEK PLMD |
| Glycation (count: 1) | 95 SPGPLDSKENLENPM PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |