P29966

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MARCS_HUMAN; P29966;
Entrez ID 4082
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Gene Name MARCKS; MACS; PRKCSL
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Sequence
(Fasta)		MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA 60
NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT 120
AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKRFSF KKSFKLSGFS FKKNKKEAGE 180
GGEAEAPAAE GGKDEAAGGA AAAAAEAGAA SGEQAAAPGE EAAAGEEGAA GGDPQEAKPQ 240
EAAVAPEKPP ASDETKAAEE PSKVEEKKAE EAGASAAACE APSAAGPGAP PEQEAAPAEE 300
PAAAAASSAC AAPSQEAQPE CSPEAPPAEA AE 333

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationC6 gliomaP8455032
[Reference]: Dissociation of phosphorylation and translocation of a myristoylated protein kinase C substrate (MARCKS protein) in C6 glioma and N1E-115 neuroblastoma cells
2PhosphorylationB-chronic lymphocytic leukemiaP8596017
[Reference]: Incubation of B-chronic lymphocytic leukemia (B-CLL) cells with phorbol esters resulted in the phosphorylation of two major PKC substrates, MARCKS (myristoylated, alanine-rich C kinase substrate) and MRP (MARCKS-related protein), and of a third protein, with an apparent m.w. of 60,000 that was the most prominent protein kinase C substrate in these cells.
3Serine PhosphorylationAlzheimer's diseaseUS4627557632
[Reference]: Here, we reveal that phosphorylation of MARCKS, a submembrane protein that regulates the stability of the actin network, occurs at Ser46 prior to aggregation of A? and is sustained throughout the course of AD in human and mouse brains.
4Serine PhosphorylationAlzheimer's diseaseUS13227557632
[Reference]: HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.
5Serine PhosphorylationAlzheimer's diseaseUS14727557632
[Reference]: HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.
6Threonine PhosphorylationAlzheimer's diseaseUT15027557632
[Reference]: HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)		MESH:D001172 ; Arthritis, Rheumatoid
MESH:D003528 ; Carcinoma, Adenoid Cystic
MESH:D012468 ; Salivary Gland Neoplasms
DisGeNet (Curated)
(count: 3)		C0003873; Rheumatoid Arthritis
C0010606; Adenoid Cystic Carcinoma
C0036095; Salivary Gland Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 28)
(view all)		 101       AAPEAGASPVEKEAP     dbPAF
118       GEAAEPGSPTAAEGE     dbPAF
120       AAEPGSPTAAEGEAA     dbPAF
128       AAEGEAASAASSTSS     dbPAF
131       GEAASAASSTSSPKA     dbPAF
132       EAASAASSTSSPKAE     dbPAF
Acetylation
(count: 5)		 11        QFSKTAAKGEAAAER     PLMD
172       KLSGFSFKKNKKEAG     PLMD
263       KAAEEPSKVEEKKAE     PLMD
69        GSAPAADKEEPAAAG     PLMD
87        ASPSAAEKGEPAAAA     PLMD
Ubiquitination
(count: 12)
(view all)		 105       AGASPVEKEAPAEGE     PLMD
11        QFSKTAAKGEAAAER     PLMD
152       SPSNETPKKKKKRFS     PLMD
165       FSFKKSFKLSGFSFK     PLMD
172       KLSGFSFKKNKKEAG     PLMD
176       FSFKKNKKEAGEGGE     PLMD
Succinylation
(count: 1)		 172       KLSGFSFKKNKKEAG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource