Tag | Content |
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UniProt Accession | PML_HUMAN; P29590; |
Entrez ID | 5371 |
GenBank Protein ID | NM_002675.3; NM_033238.2; NM_033239.2; NM_033240.2; NM_033244.3; NM_033246.2; NM_033247.2; NM_033249.2; NM_033250.2; |
GenBank Nucleotide ID | NP_002666.1; NP_150241.2; NP_150242.1; NP_150243.2; NP_150247.2; NP_150249.1; NP_150250.2; NP_150252.1; NP_150253.2; |
Protein Name | Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) |
Gene Name | PML; MYL; PP8675; RNF71; TRIM19 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP(view all) |
Sequence (Fasta) | MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE EFQFLRCQQC 60 QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD TPALDNVFFE SLQRRLSVYR 120 QIVDAQAVCT RCKESADFWC FECEQLLCAK CFEAHQWFLK HEARPLAELR NQSVREFLDG 180 TRKTNNIFCS NPNHRTPTLT SIYCRGCSKP LCCSCALLDS SHSELKCDIS AEIQQRQEEL 240 DAMTQALQEQ DSAFGAVHAQ MHAAVGQLGR ARAETEELIR ERVRQVVAHV RAQERELLEA 300 VDARYQRDYE EMASRLGRLD AVLQRIRTGS ALVQRMKCYA SDQEVLDMHG FLRQALCRLR 360 QEEPQSLQAA VRTDGFDEFK VRLQDLSSCI TQGKDAAVSK KASPEAASTP RDPIDVDLPE 420 EAERVKAQVQ ALGLAEAQPM AVVQSVPGAH PVPVYAFSIK GPSYGEDVSN TTTAQKRKCS 480 QTQCPRKVIK MESEEGKEAR LARSSPEQPR PSTSKAVSPP HLDGPPSPRS PVIGSEVFLP 540 NSNHVASGAG EAEERVVVIS SSEDSDAENS SSRELDDSSS ESSDLQLEGP STLRVLDENL 600 ADPQAEDRPL VFFDLKIDNE TQKISQLAAV NRESKFRVVI QPEAFFSIYS KAVSLEVGLQ 660 HFLSFLSSMR RPILACYKLW GPGLPNFFRA LEDINRLWEF QEAISGFLAA LPLIRERVPG 720 ASSFKLKNLA QTYLARNMSE RSAMAAVLAM RDLCRLLEVS PGPQLAQHVY PFSSLQCFAS 780 LQPLVQAAVL PRAEARLLAL HNVSFMELLS AHRRDRQGGL KKYSRYLSLQ TTTLPPAQPA 840 FNLQALGTYF EGLLEGPALA RAEGVSTPLA GRGLAERASQ QS 883 |
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Database | Annotation |
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Cancer Gene Census | APL, ALL |
CTD (Curated) (count: 7) (view all) | MESH:D005909
; Glioblastoma MESH:D008114 ; Liver Neoplasms, Experimental MESH:D015473 ; Leukemia, Promyelocytic, Acute MESH:D016609 ; Neoplasms, Second Primary MESH:D010001 ; Osteitis Deformans MESH:D012559 ; Schizophrenia |
GWASdb (count: 15) (view all) | rs3784562; Progranulin levels; frontotemporal dementia
rs3784562; Myocardial infarction; myocardial infarction rs8039584; Myopia (pathological); myopia rs12592370; Pulmonary function; asthma|chronic obstructive pulmonary disease rs11072468; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease rs3825941; Glaucoma (exfoliation); glaucoma |
PTM | Modification Sites |
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Phosphorylation (count: 46) (view all) | 117 ESLQRRLSVYRQIVD dbPAF
184 FLDGTRKTNNIFCSN dbPAF 190 KTNNIFCSNPNHRTP dbPAF 196 CSNPNHRTPTLTSIY dbPAF 22 PARPQEPTMPPPETP dbPAF 28 PTMPPPETPSEGRQP dbPAF |
Acetylation (count: 6) | 380 TDGFDEFKVRLQDLS PLMD
394 SSCITQGKDAAVSKK PLMD 476 SNTTTAQKRKCSQTQ PLMD 487 SQTQCPRKVIKMESE PLMD 497 KMESEEGKEARLARS PLMD 515 QPRPSTSKAVSPPHL PLMD |
Ubiquitination (count: 20) (view all) | 133 QAVCTRCKESADFWC PLMD
183 EFLDGTRKTNNIFCS PLMD 226 DSSHSELKCDISAEI PLMD 337 SALVQRMKCYASDQE PLMD 380 TDGFDEFKVRLQDLS PLMD 394 SSCITQGKDAAVSKK PLMD |
Sumoylation (count: 17) (view all) | 160 EAHQWFLKHEARPLA PLMD
183 EFLDGTRKTNNIFCS PLMD 209 IYCRGCSKPLCCSCA PLMD 380 TDGFDEFKVRLQDLS PLMD 394 SSCITQGKDAAVSKK PLMD 400 GKDAAVSKKASPEAA PLMD |
Malonylation (count: 1) | 394 SSCITQGKDAAVSKK PLMD |