Tag | Content |
---|---|
UniProt Accession | SHC1_HUMAN; P29353; |
Entrez ID | 6464 |
GenBank Protein ID | NM_001130040.1; NM_001130041.1; NM_001202859.1; NM_003029.4; NM_183001.4; |
GenBank Nucleotide ID | NP_001123512.1; NP_001123513.1; NP_001189788.1; NP_003020.2; NP_892113.4; |
Protein Name | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) |
Gene Name | SHC1; SHC; SHCA |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ra(view all) |
Sequence (Fasta) | MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS 60 FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR 120 RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD 180 FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS 240 LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV 300 ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL 360 GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE 420 LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA 480 EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG 540 VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL 584 |
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Database | Annotation |
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CTD (Curated) (count: 2) | MESH:C531617
; Amyotrophic lateral sclerosis 1 MESH:D006332 ; Cardiomegaly |
GWASdb (count: 4) | rs3766921; White blood cell count; hematopoietic system disease|myocardial infarction
rs4845401; White blood cell count; hematopoietic system disease|myocardial infarction rs12075984; White blood cell count; hematopoietic system disease|myocardial infarction rs12076073; White blood cell count; hematopoietic system disease|myocardial infarction |
PTM | Modification Sites |
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Phosphorylation (count: 24) (view all) | 115 LQDMNKLSGGGGRRT dbPAF
139 EEWTRHGSFVNKPTR dbPAF 145 GSFVNKPTRGWLHPN dbPAF 161 KVMGPGVSYLVRYMG dbPAF 162 VMGPGVSYLVRYMGC dbPAF 315 FELRFKQYLRNPPKL dbPAF |
Ubiquitination (count: 4) | 203 CEAVPGAKGATRRRK PLMD
279 EYVAYVAKDPVNQRA PLMD 313 QAFELRFKQYLRNPP PLMD 462 PRDLFDMKPFEDALR PLMD |