P29353

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession SHC1_HUMAN; P29353;
Entrez ID 6464
GenBank Protein ID NM_001130040.1; NM_001130041.1; NM_001202859.1; NM_003029.4; NM_183001.4;
GenBank Nucleotide ID NP_001123512.1; NP_001123513.1; NP_001189788.1; NP_003020.2; NP_892113.4;
Protein Name SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene Name SHC1; SHC; SHCA
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionSignaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ra(view all)
Sequence
(Fasta)
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS 60
FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR 120
RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD 180
FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS 240
LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV 300
ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL 360
GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE 420
LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA 480
EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG 540
VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL 584

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationLiver cancerU14676841
[Reference]: Here, we show that CD81 clustering stimulates ERK/MAPKinase activity and tyrosine phosphorylation of the adapter protein Shc in Huh7 cancer cells.
2Tyrosine PhosphorylationBreast cancer/tumor/carcinomatumor tissuePY239/24023277357
[Reference]: We demonstrate that Grb2 is required specifically downstream of Tyr(313), whereas the Tyr(239)/Tyr(240) phosphorylation sites require the Crk adaptor proteins to augment TGF-induced migration and invasion
3Tyrosine PhosphorylationBreast cancer/tumor/carcinomatumor tissuePY31323277357
[Reference]: Furthermore, ShcA Tyr(313) phosphorylation enhances tumor cell survival, and ShcA Tyr(239)/Tyr(240) signaling promotes endothelial cell recruitment into ErbB2-expressing breast tumors in vivo, whereas all three ShcA tyrosine residues are required for efficient breast cancer metastasis to the lungs.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)
MESH:C531617 ; Amyotrophic lateral sclerosis 1
MESH:D006332 ; Cardiomegaly
GWASdb
(count: 4)
rs3766921; White blood cell count; hematopoietic system disease|myocardial infarction
rs4845401; White blood cell count; hematopoietic system disease|myocardial infarction
rs12075984; White blood cell count; hematopoietic system disease|myocardial infarction
rs12076073; White blood cell count; hematopoietic system disease|myocardial infarction

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 24)
(view all)
115       LQDMNKLSGGGGRRT     dbPAF
139       EEWTRHGSFVNKPTR     dbPAF
145       GSFVNKPTRGWLHPN     dbPAF
161       KVMGPGVSYLVRYMG     dbPAF
162       VMGPGVSYLVRYMGC     dbPAF
315       FELRFKQYLRNPPKL     dbPAF
Ubiquitination
(count: 4)
203       CEAVPGAKGATRRRK     PLMD
279       EYVAYVAKDPVNQRA     PLMD
313       QAFELRFKQYLRNPP     PLMD
462       PRDLFDMKPFEDALR     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
E9PG40P29353MINT
H7C1H8P29353IntAct
O00459P29353IntAct
O00507P29353IntAct
O15027P29353IntAct
O15357P29353IntAct
O43809P29353MINT
O60674P29353MINT;HPRD
O60884P29353IntAct
O75569P29353MINT
O94832P29353IntAct
O94973P29353IntAct
O95163P29353IntAct
O95782P29353IntAct
P00533P29353DIP; IntAct; MINT;HPRD
P02549P29353IntAct
P03372P29353HPRD;IntAct
P04626P29353IntAct; MINT;HPRD
P05067P29353IntAct
P05106P29353HPRD
P05107P29353MINT
P05556P29353MINT
P05783P29353IntAct
P06213P29353DIP; IntAct; MINT
P06241P29353MINT
P07948P29353MINT
P07949P29353MINT
P08047P29353HPRD
P08069P29353DIP; IntAct
P10912P29353MINT
P12314P29353MINT
P12931P29353MINT;HPRD
P15498P29353HPRD
P16144P29353HPRD
P17252P29353HPRD
P20337P29353BioGRID
P20936P29353HPRD
P21860P29353MINT;HPRD
P22681P29353IntAct; MINT;HPRD
P26010P29353MINT
P27708P29353IntAct
P27986P29353IntAct; MINT;HPRD
P28482P29353HPRD
P29317P29353HPRD
P29353P29353BioGRID; IntAct
P29353P30519MINT
P29353P31785HPRD
P29353P32927MINT;HPRD
P29353P33151MINT;HPRD
P29353P35568HPRD
P29353P35968MINT;HPRD
P29353P36897MINT
P29353P37173MINT
P29353P41240IntAct
P29353P42229HPRD
P29353P43403MINT;HPRD
P29353P43405HPRD
P29353P45983HPRD
P29353P46108IntAct;HPRD
P29353P46109HPRD
P29353P46940MINT
P29353P49137HPRD
P29353P50570IntAct
P29353P50748BioGRID
P29353P51692HPRD
P29353P62993IntAct; MINT
P29353P63010IntAct
P29353Q04912HPRD
P29353Q05209IntAct
P29353Q05655IntAct;HPRD
P29353Q05682HPRD
P29353Q07889IntAct; MINT
P29353Q12802BioGRID
P29353Q13094MINT
P29353Q13137IntAct
P29353Q13418MINT
P29353Q14118HPRD
P29353Q14289HPRD
P29353Q15303MINT;HPRD
P29353Q16659MINT
P29353Q16832MINT
P29353Q8TDC3MINT
P29353Q8TF42IntAct
P29353Q8WXH0BioGRID
P29353Q92835MINT
P29353Q93008IntAct
P29353Q96CW1IntAct
P29353Q96RD6BioGRID
P29353Q96SB3IntAct
P29353Q9BPY3MINT
P29353Q9BTB0MINT
P29353Q9BVJ7MINT
P29353Q9BZK8BioGRID
P29353Q9H5I1MINT
P29353Q9H840MINT
P29353Q9H939IntAct
P29353Q9H9J2MINT
P29353Q9NPF4MINT
P29353Q9ULV8MINT
P29353Q9UM73HPRD
P29353Q9UQC2MINT;HPRD
P29353Q9Y4H2HPRD