P29351

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	PTN6_MOUSE; P29351;
Entrez ID	15170
GenBank Protein ID	NM_001077705.2; NM_013545.3;
GenBank Nucleotide ID	NP_001071173.1; NP_038573.2;
Protein Name	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)
Gene Name	Ptpn6; Hcp; Hcph; Ptp1C
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. Functional Description Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Sequence (Fasta)	MVRWFHRDLS GPDAETLLKG RGVPGSFLAR PSRKNQGDFS LSVRVDDQVT HIRIQNSGDF 60 YDLYGGEKFA TLTELVEYYT QQQGILQDRD GTIIHLKYPL NCSDPTSERW YHGHISGGQA 120 ESLLQAKGEP WTFLVRESLS QPGDFVLSVL NDQPKAGPGS PLRVTHIKVM CEGGRYTVGG 180 SETFDSLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA 240 KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KSKNRYKNIL PFDHSRVILQ GRDSNIPGSD 300 YINANYVKNQ LLGPDENSKT YIASQGCLDA TVNDFWQMAW QENTRVIVMT TREVEKGRNK 360 CVPYWPEVGT QRVYGLYSVT NSREHDTAEY KLRTLQISPL DNGDLVREIW HYQYLSWPDH 420 GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ESISTKGLDC 480 DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEIIQSQK GQESEYGNIT 540 YPPAVRSAHA KASRTSSKHK EEVYENVHSK SKKEEKVKKQ RSADKEKNKG SLKRK 596 Fasta Sequence >P29351\|Ptpn6; Hcp; Hcph; Ptp1C\|Mus musculus (Mouse) MVRWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHISGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNSREHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQKGQESEYGNITYPPAVRSAHAKASRTSSKHKEEVYENVHSKSKKEEKVKKQRSADKEKNKGSLKRK

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Tyrosine Phosphorylation	Chronic myelogenous leukemia/Chronic myeloid leukemia	cell line	N	Y536	20858858
1	[Reference]: In hematopoietic stem cells of lyn(-/-);PLC-?3(-/-) mice that cause the CMML-like disease, phosphorylation of SHP-1 at Tyr(536) and Tyr(564) is abrogated, resulting in reduced phosphatase activity and constitutive activation of Stat5.
2	Tyrosine Phosphorylation	Chronic myelogenous leukemia/Chronic myeloid leukemia		A	Y564	20858858
2	[Reference]: In hematopoietic stem cells of lyn(-/-);PLC-?3(-/-) mice that cause the CMML-like disease, phosphorylation of SHP-1 at Tyr(536) and Tyr(564) is abrogated, resulting in reduced phosphatase activity and constitutive activation of Stat5. Furthermore, SHP-1 phosphorylation at Tyr(564) by Lyn is indispensable for maximal phosphatase activity and for suppression of the CMML-like disease in these mice.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:D002114 ; Calcinosis MESH:D006349 ; Heart Valve Diseases MESH:D012130 ; Respiratory Hypersensitivity

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 19) (view all)	10 RWFHRDLSGPDAETL dbPAF 188 SETFDSLTDLVEHFK dbPAF 208 EASGAFVYLRQPYYA dbPAF 213 FVYLRQPYYATRVNA dbPAF 214 VYLRQPYYATRVNAA dbPAF 377 TQRVYGLYSVTNSRE dbPAF 40 RKNQGDFSLSVRVDD dbPAF 534 QSQKGQESEYGNITY dbPAF 536 QKGQESEYGNITYPP dbPAF 541 SEYGNITYPPAVRSA dbPAF 555 AHAKASRTSSKHKEE dbPAF 556 HAKASRTSSKHKEEV dbPAF 557 AKASRTSSKHKEEVY dbPAF 564 SKHKEEVYENVHSKS dbPAF 569 EVYENVHSKSKKEEK dbPAF 57 THIRIQNSGDFYDLY dbPAF 591 DKEKNKGSLKRK*** dbPAF 64 SGDFYDLYGGEKFAT dbPAF 98 GTIIHLKYPLNCSDP dbPAF
Ubiquitination (count: 1)	391 EHDTAEYKLRTLQIS PLMD
Malonylation (count: 2)	277 NKSKNRYKNILPFDH PLMD 34 FLARPSRKNQGDFSL PLMD