Tag | Content |
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UniProt Accession | EPHB2_HUMAN; P29323; |
Entrez ID | 2048 |
GenBank Protein ID | NM_001309193.1; NM_004442.7; NM_017449.4; |
GenBank Nucleotide ID | NP_001296122.1; NP_004433.2; NP_059145.2; |
Protein Name | Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyro |
Gene Name | EPHB2; DRT; EPHT3; EPTH3; ERK; HEK5; TYRO5 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of th(view all) |
Sequence (Fasta) | MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 60 VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 120 DSATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD 180 YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 240 CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 300 TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 360 ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 420 SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE 480 YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIQEK 540 LPLIIGSSAA GLVFLIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF 600 TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT 660 EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV 720 IQLVGMLRGI AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY 780 TSALGGKIPI RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE 840 QDYRLPPPMD CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI 900 NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM EDILRVGVTL 960 AGHQKKILNS IQVMRAQMNQ IQSVEGQPLA RRPRATGRTK RCQPRDVTKK TCNSNDGKKK 1020 GMGKKKTDPG RGREIQGIFF KEDSHKESND CSCGG 1056 |
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Database | Annotation |
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CTD (Curated) (count: 2) | MESH:D004806
; Ependymoma OMIM:603688 ; PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY |
DisGeNet (Curated) (count: 4) | C0014474; Ependymoma
C0376358; Malignant neoplasm of prostate C1863600; PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY (finding) C2931456; Prostate cancer, familial |
HGMD (count: 5) | CM065142; Colorectal cancer ?; Missense/nonsense
CM065141; Colorectal cancer ?; Missense/nonsense CM082613; Colorectal cancer; Missense/nonsense CM065143; Colorectal cancer ?; Missense/nonsense CM061725; Prostate cancer, incr. risk, in African Americans, assoc. with; Missense/nonsense |
GWASdb (count: 15) (view all) | rs1010011; Taste perception; sensory system disease
rs12732926; Cognitive test performance; cognitive disorder rs10753541; Serum metabolites; Null rs7516175; Schizophrenia; schizophrenia rs6692683; Suicide attempts in bipolar disorder; bipolar disorder rs893961; Multiple complex diseases; Null |
PTM | Modification Sites |
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Phosphorylation (count: 35) (view all) | 148 IAADESFSQVDLGGR dbPAF
175 PVSRSGFYLAFQDYG dbPAF 181 FYLAFQDYGGCMSLI dbPAF 194 LIAVRVFYRKCPRII dbPAF 481 YEKELSEYNATAIKS dbPAF 524 GRYSGKMYFQTMTEA dbPAF |
Ubiquitination (count: 1) | 580 ADSEYTDKLQHYTSG PLMD |
Network | Interaction | ||
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A | B | Source | |