P28799

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	GRN_HUMAN; P28799;
Entrez ID	2896
GenBank Protein ID	NM_002087.3; XM_005257253.1;
GenBank Nucleotide ID	NP_002078.1; XP_005257310.1;
Protein Name	Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granul
Gene Name	GRN
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.;Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Functional Description Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.;Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
Sequence (Fasta)	MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP 60 CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS 120 VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC PMPQASCCED RVHCCPHGAF CDLVHTRCIT 180 PTGTHPLAKK LPAQRTNRAV ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC 240 SDHLHCCPQD TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ 300 SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA HLSLPDPQAL 360 KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH QHCCPQGYTC VAEGQCQRGS 420 EIVAGLEKMP ARRASLSHPR DIGCDQHTSC PVGQTCCPSL GGSWACCQLP HAVCCEDRQH 480 CCPAGYTCNV KARSCEKEVV SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG 540 WACCPYRQGV CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL 594 Fasta Sequence >P28799\|GRN\|Homo sapiens (Human) MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Systemic lupus erythematosus		U	S81	26005049
1	[Reference]: Investigation of possible functional alterations of PGRN due to Ser81 phosphorylation revealed, that hyperphosphorylation prevents the interaction and thus direct inhibition of TNFR1, TNFR2 and DR3, representing an additional direct proinflammatory effect. Finally phosphorylation of Ser81 PGRN alters the conversion pattern of PGRN.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 7) (view all)	OMIM:614706 ; CEROID LIPOFUSCINOSIS, NEURONAL, 11 MESH:D003704 ; Dementia MESH:D057180 ; Frontotemporal Dementia MESH:D057174 ; Frontotemporal Lobar Degeneration OMIM:607485 ; FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED MESH:D008106 ; Liver Cirrhosis, Experimental MESH:D009410 ; Nerve Degeneration
DisGeNet (Curated) (count: 85) (view all)	C0001807; Aggressive behavior C0002018; Alexia C0003467; Anxiety C0003537; Aphasia C0003635; Apraxias C0005586; Bipolar Disorder C0007758; Cerebellar Ataxia C0011570; Mental Depression C0011581; Depressive disorder C0013528; Echolalia C0014550; Epilepsies, Myoclonic C0017639; Gliosis C0018524; Hallucinations C0020505; Hyperphagia C0023893; Liver Cirrhosis, Experimental C0026884; Mutism C0027746; Nerve Degeneration C0029124; Optic Atrophy C0036341; Schizophrenia C0038271; Stereotyped Behavior C0038273; Stereotypic Movement Disorder C0042798; Low Vision C0085631; Agitation C0085632; Apathy C0151611; Electroencephalogram abnormal C0232461; Increased appetite (finding) C0233794; Memory impairment C0234144; Dysgraphia C0235153; Hallucinations, Sensory C0235946; Cerebral atrophy C0240735; Personality change C0242422; Parkinsonian Disorders C0262404; Cerebellar degeneration C0312420; Hypersexuality state C0338451; Frontotemporal dementia C0338462; Semantic Dementia C0424290; Compulsive hoarding C0424296; Social disinhibition C0424323; Physical aggression C0476254; Dyslexia C0497327; Dementia C0542223; Loss of speech C0542476; Forgetful C0679145; sexual addiction C0740279; Atrophy of cerebellum C0751072; Frontotemporal Lobar Degeneration C0751295; Memory Loss C0751706; Primary Progressive Nonfluent Aphasia C0751778; Myoclonic Epilepsies, Progressive C0854723; Retinal Dystrophies C0948163; Leukoaraiosis C0973461; Dysphasia C1411876; Developmental arithmetic disorder C1457883; Aggressive reaction C1836940; Excess nuchal skin C1838320; Hyperorality C1838681; Rapidly progressive C1843792; FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED C1843793; Progressive language deterioration C1848207; Poor speech C1850496; Neuronal loss C1850776; Rapidly progressive disorder C1856409; Dilation of lateral ventricles C1969697; Repetitive compulsive behavior C2675334; Restrictive behavior, interests, and activities C2700617; Irritation - emotion C3539123; CEROID LIPOFUSCINOSIS, NEURONAL, 11 C3665347; Visual Impairment C3887611; Restlessness C4011788; Behavioral variant of frontotemporal dementia C4020851; Cortical white matter abnormalities seen on MRI C4020873; Infratentorial atrophy C4020884; Anxiety disease C4020899; Autosomal recessive predisposition C4021584; Frontotemporal cerebral atrophy C4021759; Generalized myoclonic seizures C4021799; Restrictive behavior C4022798; Abnormal brain FDG positron emission tomography C4023470; EEG with continuous slow activity C4024936; Temporal cortical atrophy C4024956; Grammar-specific speech disorder C4072928; Spoken Word Recognition Deficit C4280380; Repeated speech C4280574; Problems speaking C4280576; Difficulty making arithmetical calculations
GWASdb (count: 2)	rs3760365; Coronary artery calcification; coronary artery disease rs4792938; Coronary artery calcification; coronary artery disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 8) (view all)	11 LVSWVALTAGLVAGT dbPAF 180 LVHTRCITPTGTHPL dbPAF 182 HTRCITPTGTHPLAK dbPAF 184 RCITPTGTHPLAKKL dbPAF 295 VSCPDGYTCCRLQSG dbPAF 501 SCEKEVVSAQPATFL dbPAF 6 **MWTLVSWVALTAG dbPAF 81 IFTVSGTSSCCPFPE dbPAF
Acetylation (count: 1)	347 HQVPWMEKAPAHLSL PLMD
Sumoylation (count: 1)	428 EIVAGLEKMPARRAS PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

P13569	P28799	IntAct
P28799	P46109	IntAct
P28799	P63000	IntAct