P28667

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MRP_MOUSE; P28667;
Entrez ID 17357
GenBank Protein ID
GenBank Nucleotide ID
Protein Name MARCKS-related protein (Brain protein F52) (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)
Gene Name Marcksl1; Mlp; Mrp
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionControls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Sequence
(Fasta)		MGSQSSKAPR GDVTAEEAAG ASPAKANGQE NGHVRSNGDL TPKGEGESPP VNGTDEAAGA 60
TGDAIEPAPP SQEAEAKGEV APKETPKKKK KFSFKKPFKL SGLSFKRNRK EGGGDSSASS 120
PTEEEQEQGE MSACSDEGTA QEGKAAATPE SQEPQAKGAE ASAASKEGDT EEEAGPQAAE 180
PSTPSGPESG PTPASAEQNE 201

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationNeuroblastomaP1618855
[Reference]: The F52 protein was expressed in Escherichia coli with apparent M(r) 50,000; it was a substrate for PKC and comigrated on two-dimensional electrophoresis with a myristoylated protein whose phosphorylation was stimulated by phorbol 12-myristate 13-acetate in mouse neuroblastoma cells.


※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 27)
(view all)		 101       FKKPFKLSGLSFKRN     dbPAF
104       PFKLSGLSFKRNRKE     dbPAF
116       RKEGGGDSSASSPTE     dbPAF
117       KEGGGDSSASSPTEE     dbPAF
119       GGGDSSASSPTEEEQ     dbPAF
120       GGDSSASSPTEEEQE     dbPAF
Acetylation
(count: 1)		 106       KLSGLSFKRNRKEGG     PLMD
Ubiquitination
(count: 2)		 157       ESQEPQAKGAEASAA     PLMD
25        AAGASPAKANGQENG     PLMD