Tag | Content |
---|---|
UniProt Accession | DUS1_HUMAN; P28562; |
Entrez ID | 1843 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) |
Gene Name | DUSP1; CL100; MKP1; PTPN10; VH1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. |
Sequence (Fasta) | MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM 60 GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARAAQVFF 120 LKGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILPF 180 LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA 240 IDFIDSIKNA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS 300 FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQSP 360 ITTSPSC 368 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 4) | MESH:D001171
; Arthritis, Juvenile MESH:D003877 ; Dermatitis, Contact MESH:D004715 ; Endometriosis MESH:D017202 ; Myocardial Ischemia |
DisGeNet (Curated) (count: 6) | C0011570; Mental Depression
C0011581; Depressive disorder C0011616; Contact Dermatitis C0014175; Endometriosis C0151744; Myocardial Ischemia C3495559; Juvenile arthritis |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 7) (view all) | 140 PELCSKQSTPMGLSL dbPAF
141 ELCSKQSTPMGLSLP dbPAF 146 QSTPMGLSLPLSTSV dbPAF 296 KQRRSIISPNFSFMG dbPAF 323 HCSAEAGSPAMAVLD dbPAF 359 SALSYLQSPITTSPS dbPAF |
Acetylation (count: 1) | 57 TIVRRRAKGAMGLEH PLMD |
Ubiquitination (count: 5) | 122 AAQVFFLKGGYEAFS PLMD
280 LMRTNRVKLDEAFEF PLMD 289 DEAFEFVKQRRSIIS PLMD 57 TIVRRRAKGAMGLEH PLMD 97 SAALDGAKRDGTLAL PLMD |
Sumoylation (count: 1) | 280 LMRTNRVKLDEAFEF PLMD |
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