P28562

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession DUS1_HUMAN; P28562;
Entrez ID 1843
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)
Gene Name DUSP1; CL100; MKP1; PTPN10; VH1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionDual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Sequence
(Fasta)
MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM 60
GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARAAQVFF 120
LKGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILPF 180
LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA 240
IDFIDSIKNA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS 300
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQSP 360
ITTSPSC 368

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationMajor depressive disorderP22787484
[Reference]: Expression and phosphorylation of MKP-1, which is a key factor in MDD pathology, were both higher in the RSP2-treated group than the vehicle- and 1 mg/kg reserpine (RSP1)-treated groups (P<0.02).

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)
MESH:D001171 ; Arthritis, Juvenile
MESH:D003877 ; Dermatitis, Contact
MESH:D004715 ; Endometriosis
MESH:D017202 ; Myocardial Ischemia
DisGeNet (Curated)
(count: 6)
C0011570; Mental Depression
C0011581; Depressive disorder
C0011616; Contact Dermatitis
C0014175; Endometriosis
C0151744; Myocardial Ischemia
C3495559; Juvenile arthritis

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 7)
(view all)
140       PELCSKQSTPMGLSL     dbPAF
141       ELCSKQSTPMGLSLP     dbPAF
146       QSTPMGLSLPLSTSV     dbPAF
296       KQRRSIISPNFSFMG     dbPAF
323       HCSAEAGSPAMAVLD     dbPAF
359       SALSYLQSPITTSPS     dbPAF
Acetylation
(count: 1)
57        TIVRRRAKGAMGLEH     PLMD
Ubiquitination
(count: 5)
122       AAQVFFLKGGYEAFS     PLMD
280       LMRTNRVKLDEAFEF     PLMD
289       DEAFEFVKQRRSIIS     PLMD
57        TIVRRRAKGAMGLEH     PLMD
97        SAALDGAKRDGTLAL     PLMD
Sumoylation
(count: 1)
280       LMRTNRVKLDEAFEF     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
P05412P28562MINT
P0CG47P28562HPRD; IntAct
P24534P28562BioGRID
P27361P28562HPRD; MINT
P28482P28562HPRD; IntAct; MINT
P28562P34932HPRD
P28562P45983HPRD;MINT
P28562P45984MINT
P28562P49427IntAct
P28562P50748BioGRID
P28562P53778HPRD
P28562P61024HPRD; IntAct
P28562Q13309HPRD; IntAct
P28562Q13616IntAct
P28562Q16539IntAct; MINT;HPRD
P28562Q9P1U0IntAct