Tag | Content |
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UniProt Accession | MK01_HUMAN; P28482; |
Entrez ID | 5594 |
GenBank Protein ID | NM_002745.4; NM_138957.3; |
GenBank Nucleotide ID | NP_002736.3; NP_620407.1; |
Protein Name | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) |
Gene Name | MAPK1; ERK2; PRKM1; PRKM2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade p(view all) |
Sequence (Fasta) | MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 60 HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 120 LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH 180 TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 240 LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 300 RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS 360 361 |
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Database | Annotation |
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Cancer Gene Census | CLL, ovarian mixed germ cell tumour, cervical carcinoma |
CTD (Curated) (count: 27) (view all) | MESH:D001171
; Arthritis, Juvenile MESH:D002545 ; Brain Ischemia MESH:D002294 ; Carcinoma, Squamous Cell MESH:D009202 ; Cardiomyopathies MESH:C566627 ; Ceroid Lipofuscinosis, Neuronal, 6 MESH:D001651 ; Cholestasis, Extrahepatic |
GWASdb (count: 6) | rs13515; Heart rate; heart conduction disease
rs2283792; Multiple sclerosis; multiple sclerosis rs17759796; Atrial fibrillation; familial atrial fibrillation rs8141815; Alcohol consumption (maxi-drinks); alcohol abuse|alcohol dependence rs8141815; Heart Rate; heart conduction disease rs9610417; Amyotrophic Lateral Sclerosis; amyotrophic lateral sclerosis |
PTM | Modification Sites |
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Phosphorylation (count: 20) (view all) | 113 DLMETDLYKLLKTQH dbPAF
181 ADPDHDHTGFLTEYV dbPAF 185 HDHTGFLTEYVATRW dbPAF 187 HTGFLTEYVATRWYR dbPAF 190 FLTEYVATRWYRAPE dbPAF 193 EYVATRWYRAPEIML dbPAF |
Ubiquitination (count: 9) (view all) | 151 NVLHRDLKPSNLLLN PLMD
164 LNTTCDLKICDFGLA PLMD 272 LSLPHKNKVPWNRLF PLMD 285 LFPNADSKALDLLDK PLMD 292 KALDLLDKMLTFNPH PLMD 330 PIAEAPFKFDMELDD PLMD |
Glycation (count: 2) | 285 LFPNADSKALDLLDK PLMD
99 APTIEQMKDVYIVQD PLMD |