P28290

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	SSFA2_HUMAN; P28290;
Entrez ID	6744
GenBank Protein ID	NM_001130445.2; NM_001287503.1; NM_001287504.1; NM_006751.6;
GenBank Nucleotide ID	NP_001123917.1; NP_001274432.1; NP_001274433.1; NP_006742.2;
Protein Name	Sperm-specific antigen 2 (Cleavage signal-1 protein) (CS-1) (Ki-ras-induced actin-interacting protein)
Gene Name	SSFA2; CS1; KIAA1927; KRAP
Organism	Homo sapiens
NCBI Taxa ID	9606
Sequence (Fasta)	MDRPLSSSAE AEEELEWQVA SRRRKAWAKC RSSWQASETE DLSTEATTQD EEEDEEEDLP 60 GAQLPAAGGR GNVPNEKIAI WLKDCRTPLG ASLDEQSSST LKGVLVRNGG SFEDDLSLGA 120 EANHLHESDA QIENCNNILA KERRLQFHQK GRSMNSTGSG KSSGTVSSVS ELLELYEEDP 180 EEILYNLGFG RDEPDIASKI PSRFFNSSSF AKGIDIKVFL SAQMQRMEVE NPNYALTSRF 240 RQIEVLTTVA NAFSSLYSQV SGTPLQRIGS MSSVTSNKET DPPPPLTRSN TANRLMKTLS 300 KLNLCVDKTE KGESSSPSPS AEKGKILNVS VIEESGNKND QKSQKIMKKK ESSSMLATVK 360 EEVSGSSAAV TENADSDRIS DEANSNFNQG TENEQSKETQ SHESKLGEES GIVESKLDSD 420 FNISSHSELE NSSELKSVHI STPEKEPCAP LTIPSIRNIM TQQKDSFEME EVQSTEGEAP 480 HVPATYQLGL TKSKRDHLLR TASQHSDSSG FAEDSTDCLS LNHLQVQESL QAMGSSADSC 540 DSETTVTSLG EDLATPTAQD QPYFNESEEE SLVPLQKGLE KAAAVADKRK SGSQDFPQCN 600 TIENTGTKQS TCSPGDHIIE ITEVEEDLFP AETVELLREA SAESDVGKSS ESEFTQYTTH 660 HILKSLASIE AKCSDMSSEN TTGPPSSMDR VNTALQRAQM KVCSLSNQRM GRSLLKSKDL 720 LKQRYLFAKA GYPLRRSQSL PTTLLSPVRV VSSVNVRLSP GKETRCSPPS FTYKYTPEEE 780 QELEKRVMEH DGQSLVKSTI FISPSSVKKE EAPQSEAPRV EECHHGRTPT CSRLAPPPMS 840 QSTCSLHSIH SEWQERPLCE HTRTLSTHSV PNISGATCSA FASPFGCPYS HRHATYPYRV 900 CSVNPPSAIE MQLRRVLHDI RNSLQNLSQY PMMRGPDPAA APYSTQKSSV LPLYENTFQE 960 LQVMRRSLNL FRTQMMDLEL AMLRQQTMVY HHMTEEERFE VDQLQGLRNS VRMELQDLEL 1020 QLEERLLGLE EQLRAVRMPS PFRSSALMGM CGSRSADNLS CPSPLNVMEP VTELMQEQSY 1080 LKSELGLGLG EMGFEIPPGE SSESVFSQAT SESSSVCSGP SHANRRTGVP STASVGKSKT 1140 PLVARKKVFR ASVALTPTAP SRTGSVQTPP DLESSEEVDA AEGAPEVVGP KSEVEEGHGK 1200 LPSMPAAEEM HKNVEQDELQ QVIREIKESI VGEIRREIVS GLLAAVSSSK ASNSKQDYH 1260 Fasta Sequence >P28290\|SSFA2; CS1; KIAA1927; KRAP\|Homo sapiens (Human) MDRPLSSSAEAEEELEWQVASRRRKAWAKCRSSWQASETEDLSTEATTQDEEEDEEEDLPGAQLPAAGGRGNVPNEKIAIWLKDCRTPLGASLDEQSSSTLKGVLVRNGGSFEDDLSLGAEANHLHESDAQIENCNNILAKERRLQFHQKGRSMNSTGSGKSSGTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRMEVENPNYALTSRFRQIEVLTTVANAFSSLYSQVSGTPLQRIGSMSSVTSNKETDPPPPLTRSNTANRLMKTLSKLNLCVDKTEKGESSSPSPSAEKGKILNVSVIEESGNKNDQKSQKIMKKKESSSMLATVKEEVSGSSAAVTENADSDRISDEANSNFNQGTENEQSKETQSHESKLGEESGIVESKLDSDFNISSHSELENSSELKSVHISTPEKEPCAPLTIPSIRNIMTQQKDSFEMEEVQSTEGEAPHVPATYQLGLTKSKRDHLLRTASQHSDSSGFAEDSTDCLSLNHLQVQESLQAMGSSADSCDSETTVTSLGEDLATPTAQDQPYFNESEEESLVPLQKGLEKAAAVADKRKSGSQDFPQCNTIENTGTKQSTCSPGDHIIEITEVEEDLFPAETVELLREASAESDVGKSSESEFTQYTTHHILKSLASIEAKCSDMSSENTTGPPSSMDRVNTALQRAQMKVCSLSNQRMGRSLLKSKDLLKQRYLFAKAGYPLRRSQSLPTTLLSPVRVVSSVNVRLSPGKETRCSPPSFTYKYTPEEEQELEKRVMEHDGQSLVKSTIFISPSSVKKEEAPQSEAPRVEECHHGRTPTCSRLAPPPMSQSTCSLHSIHSEWQERPLCEHTRTLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQYPMMRGPDPAAAPYSTQKSSVLPLYENTFQELQVMRRSLNLFRTQMMDLELAMLRQQTMVYHHMTEEERFEVDQLQGLRNSVRMELQDLELQLEERLLGLEEQLRAVRMPSPFRSSALMGMCGSRSADNLSCPSPLNVMEPVTELMQEQSYLKSELGLGLGEMGFEIPPGESSESVFSQATSESSSVCSGPSHANRRTGVPSTASVGKSKTPLVARKKVFRASVALTPTAPSRTGSVQTPPDLESSEEVDAAEGAPEVVGPKSEVEEGHGKLPSMPAAEEMHKNVEQDELQQVIREIKESIVGEIRREIVSGLLAAVSSSKASNSKQDYH

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Non-small cell lung cancer/carcinoma	A549 cell line	U	S92	26947549
1	[Reference]: We confirmed that phosphorylation at Ser92 of the sperm-specific antigen 2 (SSFA2)[phospho-SSFA2 (pS92)], was related to poor prognosis. Our study demonstrates that prognostic prediction of early-stage lung adenocarcinoma is possible, and suggests new therapeutic targets for its treatment.

※ Disease Cross-ref Annotation

Database	Annotation
GWASdb (count: 2)	rs13419647; Multiple complex diseases; Null rs2303554; Statin-induced myopathy; muscular disease

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 130) (view all)	100 LDEQSSSTLKGVLVR dbPAF 1040 LRAVRMPSPFRSSAL dbPAF 1044 RMPSPFRSSALMGMC dbPAF 1045 MPSPFRSSALMGMCG dbPAF 1055 MGMCGSRSADNLSCP dbPAF 1060 SRSADNLSCPSPLNV dbPAF 1063 ADNLSCPSPLNVMEP dbPAF 111 VLVRNGGSFEDDLSL dbPAF 1115 QATSESSSVCSGPSH dbPAF 1118 SESSSVCSGPSHANR dbPAF 1121 SSVCSGPSHANRRTG dbPAF 1131 NRRTGVPSTASVGKS dbPAF 1132 RRTGVPSTASVGKSK dbPAF 1134 TGVPSTASVGKSKTP dbPAF 1138 STASVGKSKTPLVAR dbPAF 1140 ASVGKSKTPLVARKK dbPAF 1152 RKKVFRASVALTPTA dbPAF 1156 FRASVALTPTAPSRT dbPAF 1158 ASVALTPTAPSRTGS dbPAF 1161 ALTPTAPSRTGSVQT dbPAF 1163 TPTAPSRTGSVQTPP dbPAF 1165 TAPSRTGSVQTPPDL dbPAF 1168 SRTGSVQTPPDLESS dbPAF 117 GSFEDDLSLGAEANH dbPAF 1174 QTPPDLESSEEVDAA dbPAF 1175 TPPDLESSEEVDAAE dbPAF 1247 SGLLAAVSSSKASNS dbPAF 153 QFHQKGRSMNSTGSG dbPAF 156 QKGRSMNSTGSGKSS dbPAF 162 NSTGSGKSSGTVSSV dbPAF 163 STGSGKSSGTVSSVS dbPAF 165 GSGKSSGTVSSVSEL dbPAF 167 GKSSGTVSSVSELLE dbPAF 168 KSSGTVSSVSELLEL dbPAF 207 IPSRFFNSSSFAKGI dbPAF 208 PSRFFNSSSFAKGID dbPAF 209 SRFFNSSSFAKGIDI dbPAF 234 MEVENPNYALTSRFR dbPAF 270 TPLQRIGSMSSVTSN dbPAF 272 LQRIGSMSSVTSNKE dbPAF 273 QRIGSMSSVTSNKET dbPAF 275 IGSMSSVTSNKETDP dbPAF 276 GSMSSVTSNKETDPP dbPAF 280 SVTSNKETDPPPPLT dbPAF 289 PPPPLTRSNTANRLM dbPAF 291 PPLTRSNTANRLMKT dbPAF 298 TANRLMKTLSKLNLC dbPAF 300 NRLMKTLSKLNLCVD dbPAF 316 TEKGESSSPSPSAEK dbPAF 318 KGESSSPSPSAEKGK dbPAF 330 KGKILNVSVIEESGN dbPAF 352 KIMKKKESSSMLATV dbPAF 353 IMKKKESSSMLATVK dbPAF 354 MKKKESSSMLATVKE dbPAF 358 ESSSMLATVKEEVSG dbPAF 364 ATVKEEVSGSSAAVT dbPAF 367 KEEVSGSSAAVTENA dbPAF 376 AVTENADSDRISDEA dbPAF 410 ESKLGEESGIVESKL dbPAF 415 EESGIVESKLDSDFN dbPAF 419 IVESKLDSDFNISSH dbPAF 424 LDSDFNISSHSELEN dbPAF 425 DSDFNISSHSELENS dbPAF 427 DFNISSHSELENSSE dbPAF 432 SHSELENSSELKSVH dbPAF 437 ENSSELKSVHISTPE dbPAF 441 ELKSVHISTPEKEPC dbPAF 442 LKSVHISTPEKEPCA dbPAF 466 IMTQQKDSFEMEEVQ dbPAF 501 KRDHLLRTASQHSDS dbPAF 503 DHLLRTASQHSDSSG dbPAF 536 SLQAMGSSADSCDSE dbPAF 555 SLGEDLATPTAQDQP dbPAF 567 DQPYFNESEEESLVP dbPAF 591 AVADKRKSGSQDFPQ dbPAF 593 ADKRKSGSQDFPQCN dbPAF 610 ENTGTKQSTCSPGDH dbPAF 611 NTGTKQSTCSPGDHI dbPAF 641 VELLREASAESDVGK dbPAF 644 LREASAESDVGKSSE dbPAF 649 AESDVGKSSESEFTQ dbPAF 650 ESDVGKSSESEFTQY dbPAF 652 DVGKSSESEFTQYTT dbPAF 655 KSSESEFTQYTTHHI dbPAF 659 SEFTQYTTHHILKSL dbPAF 665 TTHHILKSLASIEAK dbPAF 668 HILKSLASIEAKCSD dbPAF 682 DMSSENTTGPPSSMD dbPAF 687 NTTGPPSSMDRVNTA dbPAF 704 RAQMKVCSLSNQRMG dbPAF 706 QMKVCSLSNQRMGRS dbPAF 725 KDLLKQRYLFAKAGY dbPAF 732 YLFAKAGYPLRRSQS dbPAF 737 AGYPLRRSQSLPTTL dbPAF 739 YPLRRSQSLPTTLLS dbPAF 742 RRSQSLPTTLLSPVR dbPAF 743 RSQSLPTTLLSPVRV dbPAF 746 SLPTTLLSPVRVVSS dbPAF 752 LSPVRVVSSVNVRLS dbPAF 753 SPVRVVSSVNVRLSP dbPAF 759 SSVNVRLSPGKETRC dbPAF 764 RLSPGKETRCSPPSF dbPAF 767 PGKETRCSPPSFTYK dbPAF 770 ETRCSPPSFTYKYTP dbPAF 772 RCSPPSFTYKYTPEE dbPAF 773 CSPPSFTYKYTPEEE dbPAF 775 PPSFTYKYTPEEEQE dbPAF 776 PSFTYKYTPEEEQEL dbPAF 794 VMEHDGQSLVKSTIF dbPAF 798 DGQSLVKSTIFISPS dbPAF 803 VKSTIFISPSSVKKE dbPAF 805 STIFISPSSVKKEEA dbPAF 806 TIFISPSSVKKEEAP dbPAF 840 RLAPPPMSQSTCSLH dbPAF 843 PPPMSQSTCSLHSIH dbPAF 845 PMSQSTCSLHSIHSE dbPAF 848 QSTCSLHSIHSEWQE dbPAF 864 PLCEHTRTLSTHSVP dbPAF 866 CEHTRTLSTHSVPNI dbPAF 867 EHTRTLSTHSVPNIS dbPAF 869 TRTLSTHSVPNISGA dbPAF 87 IWLKDCRTPLGASLD dbPAF 883 ATCSAFASPFGCPYS dbPAF 902 TYPYRVCSVNPPSAI dbPAF 92 CRTPLGASLDEQSSS dbPAF 923 VLHDIRNSLQNLSQY dbPAF 930 SLQNLSQYPMMRGPD dbPAF 97 GASLDEQSSSTLKGV dbPAF 98 ASLDEQSSSTLKGVL dbPAF 99 SLDEQSSSTLKGVLV dbPAF
Acetylation (count: 2)	308 KLNLCVDKTEKGESS PLMD 445 VHISTPEKEPCAPLT PLMD
Ubiquitination (count: 26) (view all)	102 EQSSSTLKGVLVRNG PLMD 1137 PSTASVGKSKTPLVA PLMD 1200 EVEEGHGKLPSMPAA PLMD 1212 PAAEEMHKNVEQDEL PLMD 1250 LAAVSSSKASNSKQD PLMD 1255 SSKASNSKQDYH*** PLMD 199 DEPDIASKIPSRFFN PLMD 212 FNSSSFAKGIDIKVF PLMD 278 MSSVTSNKETDPPPP PLMD 297 NTANRLMKTLSKLNL PLMD 301 RLMKTLSKLNLCVDK PLMD 311 LCVDKTEKGESSSPS PLMD 325 SPSAEKGKILNVSVI PLMD 397 GTENEQSKETQSHES PLMD 405 ETQSHESKLGEESGI PLMD 416 ESGIVESKLDSDFNI PLMD 664 YTTHHILKSLASIEA PLMD 672 SLASIEAKCSDMSSE PLMD 701 ALQRAQMKVCSLSNQ PLMD 729 KQRYLFAKAGYPLRR PLMD 77 RGNVPNEKIAIWLKD PLMD 785 EEEQELEKRVMEHDG PLMD 797 HDGQSLVKSTIFISP PLMD 808 FISPSSVKKEEAPQS PLMD 809 ISPSSVKKEEAPQSE PLMD 947 AAPYSTQKSSVLPLY PLMD
Sumoylation (count: 1)	808 FISPSSVKKEEAPQS PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

IntAct