| Tag | Content |
|---|---|
| UniProt Accession | CALR_HUMAN; P27797; |
| Entrez ID | 811 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60) |
| Gene Name | CALR; CRTC |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). |
| Sequence (Fasta) | MLLSVPLLLG LLGLAVAEPA VYFKEQFLDG DGWTSRWIES KHKSDFGKFV LSSGKFYGDE 60 EKDKGLQTSQ DARFYALSAS FEPFSNKGQT LVVQFTVKHE QNIDCGGGYV KLFPNSLDQT 120 DMHGDSEYNI MFGPDICGPG TKKVHVIFNY KGKNVLINKD IRCKDDEFTH LYTLIVRPDN 180 TYEVKIDNSQ VESGSLEDDW DFLPPKKIKD PDASKPEDWD ERAKIDDPTD SKPEDWDKPE 240 HIPDPDAKKP EDWDEEMDGE WEPPVIQNPE YKGEWKPRQI DNPDYKGTWI HPEIDNPEYS 300 PDPSIYAYDN FGVLGLDLWQ VKSGTIFDNF LITNDEAYAE EFGNETWGVT KAAEKQMKDK 360 QDEEQRLKEE EEDKKRKEEE EAEDKEDDED KDEDEEDEED KEEDEEEDVP GQAKDEL 418 |
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| Database | Annotation |
|---|---|
| Cancer Gene Census | MPN, MDS |
| CTD (Curated) (count: 8) (view all) | MESH:D015179
; Colorectal Neoplasms MESH:C562729 ; Esophageal Squamous Cell Carcinoma MESH:D008546 ; Melanoma, Experimental MESH:D017202 ; Myocardial Ischemia MESH:D009361 ; Neoplasm Invasiveness MESH:D055728 ; Primary Myelofibrosis |
| HGMD (count: 1) | CR061331; Schizophrenia; Regulatory
|
| GWASdb (count: 4) | rs1010222; Other erythrocyte phenotypes; hematopoietic system disease
rs1010222; Mean corpuscular hemoglobin; hematopoietic system disease rs1010222; Red blood cell traits; hematopoietic system disease rs1049481; Red blood cell traits; hematopoietic system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 13) (view all) | 109 NIDCGGGYVKLFPNS dbPAF
150 KVHVIFNYKGKNVLI dbPAF 214 KIKDPDASKPEDWDE dbPAF 22 AVAEPAVYFKEQFLD dbPAF 229 RAKIDDPTDSKPEDW dbPAF 231 KIDDPTDSKPEDWDK dbPAF |
| Acetylation (count: 16) (view all) | 143 ICGPGTKKVHVIFNY PLMD
151 VHVIFNYKGKNVLIN PLMD 153 VIFNYKGKNVLINKD PLMD 159 GKNVLINKDIRCKDD PLMD 164 INKDIRCKDDEFTHL PLMD 206 DWDFLPPKKIKDPDA PLMD |
| Ubiquitination (count: 16) (view all) | 142 DICGPGTKKVHVIFN PLMD
143 ICGPGTKKVHVIFNY PLMD 151 VHVIFNYKGKNVLIN PLMD 153 VIFNYKGKNVLINKD PLMD 159 GKNVLINKDIRCKDD PLMD 164 INKDIRCKDDEFTHL PLMD |
| Glycation (count: 8) (view all) | 143 ICGPGTKKVHVIFNY PLMD
151 VHVIFNYKGKNVLIN PLMD 153 VIFNYKGKNVLINKD PLMD 159 GKNVLINKDIRCKDD PLMD 224 EDWDERAKIDDPTDS PLMD 48 KHKSDFGKFVLSSGK PLMD |
| Malonylation (count: 3) | 143 ICGPGTKKVHVIFNY PLMD
159 GKNVLINKDIRCKDD PLMD 62 KFYGDEEKDKGLQTS PLMD |
| Succinylation (count: 5) | 151 VHVIFNYKGKNVLIN PLMD
159 GKNVLINKDIRCKDD PLMD 43 RWIESKHKSDFGKFV PLMD 48 KHKSDFGKFVLSSGK PLMD 55 KFVLSSGKFYGDEEK PLMD |