Tag | Content |
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UniProt Accession | MK03_HUMAN; P27361; |
Entrez ID | 5595 |
GenBank Protein ID | NM_001040056.2; NM_001109891.1; NM_002746.2; |
GenBank Nucleotide ID | NP_001035145.1; NP_001103361.1; NP_002737.2; |
Protein Name | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) |
Gene Name | MAPK3; ERK1; PRKM3 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade p(view all) |
Sequence (Fasta) | MAAAAAQGGG GGEPRRTEGV GPGVPGEVEM VKGQPFDVGP RYTQLQYIGE GAYGMVSSAY 60 DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAS TLEAMRDVYI 120 VQDLMETDLY KLLKSQQLSN DHICYFLYQI LRGLKYIHSA NVLHRDLKPS NLLINTTCDL 180 KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS 240 NRPIFPGKHY LDQLNHILGI LGSPSQEDLN CIINMKARNY LQSLPSKTKV AWAKLFPKSD 300 SKALDLLDRM LTFNPNKRIT VEEALAHPYL EQYYDPTDEP VAEEPFTFAM ELDDLPKERL 360 KELIFQETAR FQPGVLEAP |
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Database | Annotation |
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CTD (Curated) (count: 27) (view all) | MESH:D001284
; Atrophy MESH:D002545 ; Brain Ischemia MESH:D002294 ; Carcinoma, Squamous Cell MESH:D009202 ; Cardiomyopathies MESH:C566627 ; Ceroid Lipofuscinosis, Neuronal, 6 MESH:D001651 ; Cholestasis, Extrahepatic |
PTM | Modification Sites |
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Phosphorylation (count: 16) (view all) | 130 DLMETDLYKLLKSQQ dbPAF
170 LHRDLKPSNLLINTT dbPAF 198 ADPEHDHTGFLTEYV dbPAF 202 HDHTGFLTEYVATRW dbPAF 204 HTGFLTEYVATRWYR dbPAF 207 FLTEYVATRWYRAPE dbPAF |
Acetylation (count: 3) | 220 PEIMLNSKGYTKSID PLMD
287 YLQSLPSKTKVAWAK PLMD 294 KTKVAWAKLFPKSDS PLMD |
Ubiquitination (count: 11) (view all) | 168 NVLHRDLKPSNLLIN PLMD
181 INTTCDLKICDFGLA PLMD 220 PEIMLNSKGYTKSID PLMD 287 YLQSLPSKTKVAWAK PLMD 289 QSLPSKTKVAWAKLF PLMD 294 KTKVAWAKLFPKSDS PLMD |
Sumoylation (count: 1) | 357 MELDDLPKERLKELI PLMD |
Malonylation (count: 1) | 220 PEIMLNSKGYTKSID PLMD |
Methylation (count: 2) | 302 LFPKSDSKALDLLDR PLMD
361 DLPKERLKELIFQET PLMD |