P26678

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PPLA_HUMAN; P26678;
Entrez ID 5350
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Cardiac phospholamban (PLB)
Gene Name PLN; PLB
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionReversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Sequence
(Fasta)		MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL 53

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationMetabolic syndrome/diseasetumor tissuePS1623458196
[Reference]: The amount of sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) 2a, phospholamban (PLB) protein, and Ser(16)-phosphorylated PLB was decreased in cardiomyocytes from SHRSP fatty rats compared with those from control Wistar-Kyoto rats at 18 weeks of age, and the PLB-to-SERCA2a ratio was increased

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 6)		MESH:C563690 ; Cardiomyopathy, Dilated, 1p
OMIM:613874 ; CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 18
MESH:D009203 ; Myocardial Infarction
MESH:D015428 ; Myocardial Reperfusion Injury
MESH:D017682 ; Myocardial Stunning
MESH:D018487 ; Ventricular Dysfunction, Left
HGMD
(count: 5)		CD060646; Cardiomyopathy; Small deletions
CM030490; Cardiomyopathy, dilated; Missense/nonsense
CM030697; Cardiomyopathy, dilated; Missense/nonsense
CR075266; Cardiomyopathy, hypertrophic; Regulatory
CR082029; Cardiomyopathy, dilated; Regulatory

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 2)		 16        RSAIRRASTIEMPQQ     dbPAF
17        SAIRRASTIEMPQQA     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource